Apparatus and methods for ocular injection

Patent metadata

Field	Value
Publication number	US-9937075-B2
Application number	US-201715714441-A
Country	US
Kind code	B2
Filing date	Sep 25, 2017
Priority date	May 3, 2013
Publication date	Apr 10, 2018
Grant date	Apr 10, 2018

Abstract

An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

First claim

The invention claimed is:

1. An apparatus, comprising:
a medicament container, the medicament container including triamcinolone;
a housing configured to receive a portion of the medicament container;
a hub configured to be coupled to the medicament container and defining a passageway through which a puncture member is disposed, the hub being fixedly coupled to the puncture member such that the hub moves with the puncture member when the puncture member is moved relative to an eye, a distal end surface of the hub having a convex surface and being configured to contact a target surface of the eye when the triamcinolone is conveyed through the puncture member; and
an actuation rod at least partially disposed within the medicament container,
the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a suprachoroidal space of the eye, and (2) movement of a distal end portion of the actuation rod within the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within an upper portion of a sclera of the eye, the force having a magnitude less than a threshold value.

2. The apparatus of claim 1 , wherein the triamcinolone is triamcinolone acetonide.

3. The apparatus of claim 1 , wherein the threshold value is from about 2N to about 6N.

4. The apparatus of claim 1 , wherein the target surface is any one of a conjunctiva of the eye or the sclera of the eye.

5. The apparatus of claim 1 , wherein the distal end surface of the hub includes a sealing portion configured to define a substantially fluid-tight seal with the target surface when the triamcinolone is conveyed through the puncture member.

6. The apparatus of claim 5 , wherein the sealing portion is symmetrical about a centerline of the passageway of the hub.

7. The apparatus of claim 1 , wherein a centerline of the puncture member is substantially normal to a surface line tangent to the hub.

8. The apparatus of claim 1 , wherein the force is between about 0.5N and about 2N.

9. The apparatus of claim 1 , wherein the force is applied manually.

10. The apparatus of claim 1 , wherein the hub is configured to be coupled to the medicament container via a threaded coupling.

11. The apparatus of claim 1 , wherein at least a portion of the medicament container is transparent.

12. A kit, comprising:
a vial containing triamcinolone; and
a medical injector, the medical injector including:
a housing, the housing configured to be coupled to a medicament container;
the medicament container, the medicament container configured to receive the triamcinolone from the vial;
a hub, the hub configured to be coupled to the medicament container and defining a passageway through which a puncture member is disposed, the puncture member being fixedly coupled to the hub, at least a portion of a distal end surface of the hub having (1) a hemispherical shape, and (2) a sealing portion configured to define a substantially fluid-tight seal with a target surface of an eye when the triamcinolone is conveyed through the puncture member; and
an actuation rod, the actuation rod configured to be at least partially disposed within the medicament container,
the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a suprachoroidal space of the eye, and (2) movement of a distal end portion of the actuation rod within the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within an upper portion of a sclera of the eye, the force having a magnitude less than a threshold value.

13. The kit of claim 12 , wherein the triamcinolone is triamcinolone acetonide.

14. The kit of claim 12 , wherein the threshold value is from about 2N to about 6N.

15. The kit of claim 12 , wherein the target surface is any one of a conjunctiva of the eye or the sclera of the eye.

16. The kit of claim 12 , wherein the sealing portion is symmetrical about a centerline of the passageway of the hub.

17. The kit of claim 12 , wherein a centerline of the puncture member is substantially normal to a surface line tangent to the hub.

18. The kit of claim 12 , wherein the force is between about 0.5N and about 2N.

19. The kit of claim 12 , wherein the force is applied manually.

20. The kit of claim 12 , wherein the hemispherical shape is convex.

21. The kit of claim 12 , wherein the hub is configured to be coupled to the medicament container via a threaded coupling.

22. The kit of claim 12 , wherein at least a portion of the medicament container is transparent.

23. An apparatus, comprising:
a medicament container configured to contain triamcinolone;
a housing configured to receive a portion of the medicament container;
a hub configured to be coupled to the medicament container and defining a passageway through which a puncture member is disposed, the hub being fixedly coupled to the puncture member such that the hub moves with the puncture member when the puncture member is moved relative to an eye, a distal end surface of the hub having a convex surface and being configured to contact a target surface of the eye when the triamcinolone is conveyed through the puncture member; and
an actuation rod at least partially disposed within the medicament container,
the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a suprachoroidal space of the eye, and (2) movement of a distal end portion of the actuation rod within the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within an upper portion of a sclera of the eye, the force having a magnitude less than a threshold value.

24. The apparatus of claim 23 , wherein the triamcinolone is triamcinolone acetonide.

25. The apparatus of claim 23 , wherein the threshold value is from about 2N to about 6N.

26. The apparatus of claim 23 , wherein a centerline of the puncture member is substantially normal to a surface line tangent to the hub.

27. The apparatus of claim 23 , wherein the force is between about 0.5N and about 2N.

28. The apparatus of claim 23 , wherein the force is applied manually.

Assignees

• Clearside Biomedical Inc

Inventors

• Andino Rafael Victor
• Zarnitsyn Vladimir
• Yoo Jesse
• Brooks Christopher John
• Kahute Trent John
• Arsenault Justin William
• Trettin David Jackson
• Bauer Andrew Kent
• Lewis Stephanie Elaine

Classifications

• A61M5/2053

  Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155) · CPC title

• A61M37/0015

  by using microneedles · CPC title

• A61M5/31

  Details · CPC title

• A61M2037/0061

  Methods for using microneedles · CPC title

• A61M5/482

  Varying injection pressure, e.g. by varying speed of injection · CPC title