Slippery liquid-infused porous surfaces and biological applications thereof

Patent metadata

Field	Value
Publication number	US-9932484-B2
Application number	US-201213980858-A
Country	US
Kind code	B2
Filing date	Jan 19, 2012
Priority date	Jan 19, 2011
Publication date	Apr 3, 2018
Grant date	Apr 3, 2018

Abstract

A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

First claim

What is claimed is:

1. A method of preventing, reducing, or delaying adhesion, adsorption, surface-mediated clot formation, or coagulation of a biological material onto a device in contact therewith, comprising:
providing the device comprising a substrate comprising a roughened surface, wherein the roughened surface comprises one or more functional groups chemically attached to the roughened surface, wherein the roughened surface has a roughness factor, R, greater than or equal to 1, where the roughness factor is defined as the ratio between the real surface area and the projected surface area; and a lubricating liquid wetting and adhering to the roughened surface to form a stabilized liquid overlayer, wherein the lubricating liquid covers the roughened surface, and wherein the one or more functional groups attached to the roughened surface and the lubricating liquid have an affinity for each other and the roughness factor is selected such that the lubricating liquid is immobilized in, on and over the functionalized roughened surface; and
contacting the biological material to the device so that the stabilized liquid overlayer prevents, reduces, or delays adhesion, adsorption, surface-mediated clot formation or coagulation of the biological material onto the device.

2. The method of claim 1 , wherein the device is selected from the group consisting of a cannula, connector, catheter, needle, capillary tube, tubing, syringe and combinations thereof.

3. The method of claim 1 , wherein the device is selected from the group consisting of a slide, plate, film, work surface, well, well plate, Petri dish, tile, jar, flask, beaker, vial, test tube, column, container, cuvette, bottle, drum, vat, tank, and combinations thereof.

4. The method of claim 1 , wherein the device is selected from the group consisting of an organ, artificial organ, implant, stent and combinations thereof.

5. The method of claim 1 , wherein the substrate is roughened using photolithography, projection lithography, e-beam writing or lithography, depositing nanowire arrays, growing nanostructures on the surface of a substrate, soft lithography, replica molding, solution deposition, solution polymerization, electropolymerization, electrospinning, electroplating, vapor deposition, layered deposition, rotary jet spinning of polymer nanofibers, contact printing, etching, transfer patterning, microimprinting, self-assembly, boehmite (γ-AlO(OH)) formation, spray coated, and combinations thereof.

6. The method of claim 1 , wherein the substrate comprises polymers, metals, sapphire, glass, diamond, graphite, black carbon, or ceramics.

7. The method of claim 1 , wherein the biological material comprises a simple aqueous fluid, a complex aqueous fluid, a solidified fluid, whole blood, plasma, serum, sweat, feces, urine, saliva, tears, vaginal fluid, prostatic fluid, gingival fluid, amniotic fluid, intraocular fluid, cerebrospinal fluid, seminal fluid, sputum, ascites fluid, pus, nasopharengal fluid, wound exudate fluid, aqueous humour, vitreous humour, bile, cerumen, endolymph, perilymph, gastric juice, mucus, peritoneal fluid, pleural fluid, sebum, vomit, or combinations thereof.

8. The method of claim 1 , wherein the biological material is a natural or synthetic solution used in medicines, intravenous solutions, pharmaceutical manufacturing, or medication delivery systems.

9. The method of claim 1 , wherein the substrate comprises one or more of polydimethylsiloxane, polypropylene, polytetrafluoroethylene, fluoro-silanized metals, fluoro-silanized natural polymers, fluoro-silanized synthetic polymers, polytetrafluoroethylene (PTFE), polyvinylfluoride, polyvinylidene fluoride, and fluorinated ethylene propylene.

10. The method of claim 1 , wherein the lubricating liquid has a density greater than the density of the biological material.

11. The method of claim 1 , wherein the lubricating liquid comprises a fluid selected from the group consisting of tertiary perfluoroalkylamines, perfluorotri-n-butylamine, perfluoroalkylsulfides, perfluoroalkylsulfoxides, perfluoroalkylethers, perfluorocycloethers, perfluoropolyethers, perfluoroalkylphosphines, and perfluoroalkylphosphineoxides, and combinations thereof.

12. The method of claim 1 , wherein the method prevents, reduces, or delays bacterial contamination or biofilm formation onto the device.

13. The method of claim 1 , wherein the biological material comprises blood and the stabilized liquid overlayer prevents coagulation of blood onto the device.

14. The method of claim 1 , wherein the device is selected from the group consisting of a clamp, skin hook, cuff, retractor, shunt, needle, capillary tube, tubing, and combinations thereof.

15. The method of claim 1 , wherein the device is selected from the group consisting of an endotracheal tube, ventilator, associated ventilator tubing, drug delivery vehicle, intrauterine device, syringe, endoscope, and combinations thereof.

16. The method of claim 1 , wherein the device is selected from a biosensor, an optical window, endoscope, colonoscope or combinations thereof.

17. The method of claim 1 , wherein the device is a wound dressing.

18. The method of claim 1 , wherein the substrate is a roughened surface comprising a porous material.

19. The method of claim 1 , wherein the lubricating liquid infiltrates the substrate by capillary action.

20. The method of claim 1 , wherein the lubricating liquid is capable of self-healing by wicking back to any damaged region of the substrate after physical damage.

21. The method of claim 1 , wherein the substrate is silanized.

22. The method of claim 1 , wherein the lubricating liquid comprises a perfluorinated liquid, liquid silicone elastomers, vegetable or mineral oil, liquid hydrocarbons, or combinations thereof.

23. The method of claim 1 , wherein the biological material comprises a simple aqueous fluid, a complex aqueous fluid, a solidified fluid, whole blood, plasma, serum, sweat, feces, urine, saliva, tears, vaginal fluid, prostatic fluid, gingival fluid, amniotic fluid, intraocular fluid, cerebrospinal fluid, seminal fluid, sputum, ascites fluid, pus, nasopharengal fluid, wound exudate fluid, aqueous humour, vitreous humour, bile, cerumen, endolymph, perilymph, gastric juice, mucus, peritoneal fluid, pleural fluid, sebum, vomit, or combinations thereof.

24. The method of claim 1 , wherein the biological material is a solution or suspension containing particles selected from the group consisting of normal cells, diseased cells, parasitized cells, cancer cells, foreign cells, stem cells, and infected cells, microorganisms, viruses, virus-like particles, bacteria, bacteriophages, proteins, cellular components, cell organelles, cell fragments, cell membranes, cell membrane fragments, viruses, virus-like particles, bacteriophage, cytosolic proteins, secreted proteins, signaling molecules, embedded proteins, nucleic acid/protein complexes, nucleic acid precipitants, chromosomes, nuclei, mitochondria, chloroplasts, flagella, biominerals, protein complexes, and minicells.

25. The method of claim 1 , wherein said contacting the biological material to the device is carried out without forcing the biological material against the device by an opposing device.

26. The method of claim 2 , wherein the device is a catheter.

27. The method of claim 2 , wherein the device is a tubing.

Assignees

• Aizenberg Joanna
• Hatton Benjamin
• Ingber Donald
• Super Michael
• Wong Tak Sing
• Harvard College

Inventors

• Aizenberg Joanna
• Hatton Benjamin
• Ingber Donald
• Super Michael
• Wong Tak Sing

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L15/42

  Use of materials characterised by their function or physical properties (liquid bandages A61L26/00) · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L15/34

  Oils, fats, waxes or natural resins {(A61L15/225 takes precedence)} · CPC title

• C09D5/1681

  Antifouling coatings characterised by surface structure, e.g. for roughness effect giving superhydrophobic coatings or Lotus effect · CPC title