Method for visualising biomolecules, such as proteins or nucleic acids, with the unaided eye, without needing to use potentiallly toxic compounds, exposure to ultraviolet (uv) light or fluorescence
US-2017356919-A1 · Dec 14, 2017 · US
Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
US9932479B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9932479-B2 |
| Application number | US-201514812171-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 29, 2015 |
| Priority date | Nov 30, 2009 |
| Publication date | Apr 3, 2018 |
| Grant date | Apr 3, 2018 |
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- Title
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Abstract
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Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.
First claim
Opening claim text (preview).
What is claimed is: 1. The dye TOL-11. 2. The dye TOL-2. 3. The dye TOL-6. 4. A kit comprising one or more dyes selected from the group consisting of TOL-11, TOL-2, and TOL-6. 5. The kit of claim 4 , further comprising a dye selected from the group consisting of S-43, S13, S-39, and S-42. 6. The kit of claim 4 , further comprising a dye selected from the group consisting of YAT-2134, YAT-2148, YAT-2149, YAT-2150, YAT-2135, YAT-2214, YAT-2213, and YAT-2324. 7. The kit of claim 4 , comprising more than one dye selected from the group consisting TOL-11, TOL-2, and TOL-6.
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Classifications
with fluorescent label · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
substituted on the polymethine chain · CPC title
the substituent being bound through an oxygen atom · CPC title
two heterocyclic rings linked carbon-to-carbon (C09B7/00 takes precedence) · CPC title
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- What does patent US9932479B2 cover?
- Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes i…
- Who is the assignee on this patent?
- Enzo Biochem Inc
- What technology area does this patent fall under?
- Primary CPC classification C09B23/145. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 03 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).