8-carboxamido-2,6-methano-3-benzazocines

Patent metadata

Field	Value
Publication number	US-9932349-B2
Application number	US-201615260610-A
Country	US
Kind code	B2
Filing date	Sep 9, 2016
Priority date	Oct 31, 2000
Publication date	Apr 3, 2018
Grant date	Apr 3, 2018

Abstract

8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH 2 —OH, —CH 2 NH 2 , —NHSO 2 CH 3 ,

and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.

8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.

First claim

I claim:

1. The compound:

Assignees

• Rensselaer Polytech Inst

Inventors

• Wentland Mark P

Classifications

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P25/36

  Opioid-abuse · CPC title