Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones

Patent metadata

Field	Value
Publication number	US-9932323-B2
Application number	US-201715406163-A
Country	US
Kind code	B2
Filing date	Jan 13, 2017
Priority date	Sep 11, 2012
Publication date	Apr 3, 2018
Grant date	Apr 3, 2018

Abstract

The invention provides compounds of formula I:

and salts and prodrugs thereof wherein R 4 , X 1 and X 2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

First claim

What is claimed is:

1. A compound which is:

or a salt thereof.

2. A compound which is:

or a salt thereof.

3. A pharmaceutical composition comprising a compound as described in claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.

4. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable diluent or carrier.

5. A method to promote an antiviral effect in an animal comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof, to the animal.

6. A method to inhibit an endonuclease in an animal in need of such treatment comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof, to the animal.

7. A method to inhibit an exonuclease in an animal in need of such treatment comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof, to the animal.

8. A method to treat influenza in an animal comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof, to the animal.

9. A method to treat HIV in an animal comprising administering a compound as described in claim 1 , or a pharmaceutically acceptable salt thereof, to the animal.

10. A method to promote an antiviral effect in an animal comprising administering a compound of claim 2 , or a pharmaceutically acceptable salt thereof, to the animal.

11. A method to inhibit an endonuclease in an animal in need of such treatment comprising administering a compound claim 2 , or a pharmaceutically acceptable salt thereof, to the animal.

12. A method to inhibit an exonuclease in an animal in need of such treatment comprising administering a compound of claim 2 , or a pharmaceutically acceptable salt thereof, to the animal.

13. A method to treat influenza in an animal comprising administering a compound of claim 2 , or a pharmaceutically acceptable salt thereof, to the animal.

14. A method to treat HIV in an animal comprising administering a compound of claim 2 , or a pharmaceutically acceptable salt thereof, to the animal.

Assignees

• Univ Rutgers

Inventors

• Lavoie Edmond J
• Bauman Joseph David
• Parhi Ajit
• Sagong Hye Yeon
• Patel Disha
• Arnold Eddy
• Das Kalyan
• Vijayan Suyambu Kesava

Classifications

• C07D213/74

  Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals · CPC title

• C07D237/16

  Two oxygen atoms · CPC title

• C07D239/54

  as doubly bound oxygen atoms or as unsubstituted hydroxy radicals · CPC title

• C07D401/14

  containing three or more hetero rings · CPC title

• C07D401/10

  linked by a carbon chain containing aromatic rings · CPC title