N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation

Patent metadata

Field	Value
Publication number	US-9932300-B2
Application number	US-201615216057-A
Country	US
Kind code	B2
Filing date	Jul 21, 2016
Priority date	May 28, 2009
Publication date	Apr 3, 2018
Grant date	Apr 3, 2018

Abstract

Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

First claim

What is claimed is:

1. A compound of formula

Assignees

• Harvard College

Inventors

• Aktas Bertal Huseyin
• Halperin José A
• Chorev Michael

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• C07D249/14

  Nitrogen atoms · CPC title

• C07D213/75 Primary

  Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title