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Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
US9931317B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9931317-B2 |
| Application number | US-201715399562-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 5, 2017 |
| Priority date | Feb 19, 2013 |
| Publication date | Apr 3, 2018 |
| Grant date | Apr 3, 2018 |
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- Title
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Abstract
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The present invention relates to compounds of formula I: in which n, m, X, Y 1 , R 1 , R 2 , R 3 , R 4 and R 5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.
First claim
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We claim: 1. A method of treating breast cancer, comprising administering to a subject in need of such treatment an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the structure: in combination with 4-[2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)piperazin-1-yl]methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine.
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containing a heterocyclic ring having sulfur as a ring hetero atom · CPC title
1,2,4-Triazoles · CPC title
Antineoplastic agents · CPC title
Nitrogen atoms not forming part of a nitro radical · CPC title
condensed with carbocyclic rings · CPC title
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- What does patent US9931317B2 cover?
- The present invention relates to compounds of formula I: in which n, m, X, Y 1 , R 1 , R 2 , R 3 , R 4 and R 5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a pr…
- Who is the assignee on this patent?
- Novartis Ag
- What technology area does this patent fall under?
- Primary CPC classification A61K31/381. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 03 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).