Inhibitors of DXP synthase and methods of use thereof

Patent metadata

Field	Value
Publication number	US-9930893-B2
Application number	US-201514618589-A
Country	US
Kind code	B2
Filing date	Feb 10, 2015
Priority date	Feb 10, 2014
Publication date	Apr 3, 2018
Grant date	Apr 3, 2018

Abstract

Novel inhibitors of DXP synthase and methods of use thereof are disclosed.

First claim

What is claimed is:

1. A pharmaceutical composition comprising a compound represented by the formula:

in which
X is phenyl;
R 1 , independently is absent, or if present, is halo or optionally substituted C 1 -C 4 alkyl; and,
n is 1;

or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.

2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises:

Assignees

• Univ Johns Hopkins

Inventors

• Freel Meyers Caren L
• Morris Francine
• Vierling Ryan J

Classifications

• C07F9/4065

  Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se) · CPC title

• A01N57/22 Primary

  containing aromatic radicals · CPC title

• C07F9/4078

  Esters with unsaturated acyclic alcohols · CPC title

• C07F9/6539 Primary

  Five-membered rings · CPC title

• C07F9/4087

  Esters with arylalkanols · CPC title