Processes for producing coenzyme Q10
US-9315839-B2 · Apr 19, 2016 · US
Process for producing coenzyme Q10
US9926580B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9926580-B2 |
| Application number | US-201615076025-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 21, 2016 |
| Priority date | Dec 27, 2001 |
| Publication date | Mar 27, 2018 |
| Grant date | Mar 27, 2018 |
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Abstract
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A process for producing on an industrial scale the oxidized coenzyme Q 10 , includes culturing a reduced coenzyme Q 10 -producing microorganism selected from the group consisting of the genus Rhodobacter , the genus Saitoella , the genus Schizosaccharomyces and the genus Trichosporon , to obtain microbial cells containing reduced coenzyme Q 10 at a ratio of not less than 70 mole % among the entire coenzymes Q 10 ; and one of: (a) oxidizing thus-obtained reduced coenzyme Q 10 to oxidized coenzyme Q 10 and then extracting the oxidized coenzyme Q 10 by an organic solvent; or (b) extracting reduced coenzyme Q 10 by an organic solvent and oxidizing the extracted reduced coenzyme Q 10 to oxidized coenzyme Q 10 .
First claim
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What is claimed is: 1. A process for producing on an industrial scale the oxidized coenzyme Q 10 , comprising: aerobically culturing a reduced coenzyme Q 10 -producing microorganism selected from the group consisting of the genus Rhodobacter , the genus Saitoella , the genus Schizosaccharomyces and the genus Trichosporon , to obtain microbial cells containing reduced coenzyme Q 10 at a ratio of not less than 70 mole % among the entire coenzymes Q 10 ; and one of: (a) oxidizing thus-obtained reduced coenzyme Q 10 to oxidized coenzyme Q 10 and then extracting the oxidized coenzyme Q 10 by an organic solvent; or (b) extracting reduced coenzyme Q 10 by an organic solvent and oxidizing the extracted reduced coenzyme Q 10 to oxidized coenzyme Q 10 . 2. The process according to claim 1 , wherein the extraction of the oxidized coenzyme Q 10 is carried out by using a hydrophilic organic solvent. 3. The process according to claim 1 , wherein the extraction of reduced coenzyme Q 10 is carried out using a hydrophilic organic solvent. 4. The process according to claim 1 , wherein the extraction of the oxidized coenzyme Q 10 is carried out by using a hydrophobic organic solvent. 5. The process according to claim 1 , wherein the extraction of reduced coenzyme Q 10 is carried out using a hydrophobic organic solvent. 6. The process according to claim 1 , wherein the reduced coenzyme Q 10 is oxidized with an oxidizing agent. 7. The process according to claim 6 , wherein the oxidizing agent is manganese dioxide. 8. The process according to claim 1 , wherein the oxidized coenzyme Q 10 is extracted by a continuous extraction. 9. The process according to claim 1 , wherein the reduced coenzyme Q 10 is extracted by a continuous extraction. 10. The process according to claim 8 , wherein the continuous extraction is a countercurrent multistage extraction. 11. The process according to claim 9 , wherein the continuous extraction is a countercurrent multistage extraction. 12. The process according to claim 1 , wherein the reduced coenzyme Q 10 has a ratio of not less than 70 mole % among the entire coenzymes Q 10 when measured under the condition that the reduced coenzyme Q 10 is protected from an oxidation reaction. 13. The process according to claim 1 , wherein step (a) or step (b) is conducted under an inert gas atmosphere. 14. The process according to claim 13 , wherein the inert gas atmosphere comprises nitrogen gas. 15. The process according to claim 1 , wherein the culturing is carried out with at least 750 L of culture medium. 16. The process according to claim 1 , further comprising the step of disrupting the microbial cells. 17. The process according to claim 1 , wherein the culturing is conducted in a culture medium containing a carbon source, a nitrogen source, a phosphorus source and a micronutrient.
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- What does patent US9926580B2 cover?
- A process for producing on an industrial scale the oxidized coenzyme Q 10 , includes culturing a reduced coenzyme Q 10 -producing microorganism selected from the group consisting of the genus Rhodobacter , the genus Saitoella , the genus Schizosaccharomyces and the genus Trichosporon , to obtain microbial cells containing reduced coenzyme Q 10 at a ratio of not less than 70 mole % among t…
- Who is the assignee on this patent?
- Kaneka Corp
- What technology area does this patent fall under?
- Primary CPC classification C12P7/66. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 27 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).