Crystalline forms of an androgen receptor modulator
US-2015133481-A1 · May 14, 2015 · US
Synthesis of thiohydantoins
US9926291B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9926291-B2 |
| Application number | US-201615370093-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 6, 2016 |
| Priority date | Mar 27, 2007 |
| Publication date | Mar 27, 2018 |
| Grant date | Mar 27, 2018 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of synthesizing a compound of formula: the method comprising: reacting a compound of formula: wherein R 1 is or —CN, with in the presence of a source of cyanide to provide a compound of formula: 2. The method of claim 1 , wherein R 1 is 3. The method of claim 1 , wherein R 1 is —CN. 4. The method of claim 1 , wherein the source of cyanide is NaCN. 5. The method of claim 1 , wherein the source of cyanide is KCN. 6. The method of claim 1 further comprising purifying the product of the step of reacting by recrystallization. 7. The method of claim 1 further comprising purifying the product of the step of reacting by column chromatography. 8. The method of claim 1 further comprising purifying the product of the step of reacting by distillation.
Assignees
Inventors
Classifications
Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals · CPC title
Halogen atoms or nitro radicals · CPC title
by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups · CPC title
2-Phenoxypyridines; Derivatives thereof · CPC title
Nitriles · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US9926291B2 cover?
- A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
- Who is the assignee on this patent?
- Sloan Kettering Inst Cancer Res
- What technology area does this patent fall under?
- Primary CPC classification C07D401/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 27 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).