Molecular imaging

Patent metadata

Field	Value
Publication number	US-9925278-B2
Application number	US-200913125842-A
Country	US
Kind code	B2
Filing date	Oct 6, 2009
Priority date	Oct 23, 2008
Publication date	Mar 27, 2018
Grant date	Mar 27, 2018

Abstract

An imaging system includes a radiation source ( 110 ) that emits radiation that traverses an examination region and a detector ( 116 ) that detects radiation traversing the examination region and a subject disposed therein, and produces a signal indicative of the energy of the detected radiation. A data selector ( 122 ) energy discriminates the signal based on an energy spectra setting corresponding to first and second spectral characteristics of a contrast agent administered to the subject, wherein the contrast agent has a first attenuation spectral characteristic when attached to the target and a second different spectral characteristic when not attached to the target. A reconstructor ( 134 ) reconstructs the signal based on the first and second spectral characteristics and generates volumetric image data indicative of the target.

First claim

The invention is claimed to be:

1. An imaging system, comprising:
a radiation source that emits radiation that traverses an examination region;
a detector that detects radiation traversing the examination region and a subject disposed therein, and produces a signal indicative of an energy of the radiation detected by the detector;
a data selector that energy discriminates the signal based on an energy spectra setting corresponding to first and second spectral characteristics of a contrast agent administered to the subject, wherein the contrast agent has a first attenuation spectral characteristic when attached to a target and a second different spectral characteristic when not attached to the target; and
a reconstructor that reconstructs the signal based on the first and second spectral characteristics and generates volumetric image data indicative of the target.

2. The imaging system of claim 1 , wherein the contrast agent includes at least two K-edge materials, and the energy spectra of the radiation emitted by the radiation source and the radiation detected by the detector are based on the at least two K-edge materials.

3. The imaging system of claim 1 , wherein the contrast agent includes a structure with at least two materials with different spectral characteristics, and a first material of the at least two materials disassociates from the structure when the structure attaches to the target, thereby changing a spectral characteristic of the structure from the first spectral characteristic to a second spectral characteristic.

4. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and differentiates between the at least two materials based on the first and second spectral characteristics.

5. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and determines a ratio of radiation attenuation values of the at least two materials.

6. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and determines values indicative of attenuation values of at least one of the at least two materials at different locations in the subject.

7. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and determines a time when the contrast agent attached to the target.

8. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and determines at least one of a local or a global concentration of the contrast agent in one or more regions of the subject.

9. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and determines a rate of change of a presence of the contrast agent in the subject.

10. The imaging system of claim 3 , further including a processing component that processes the signal or the volumetric image data and provides a quantitative assessment of targeting sites.

11. A method, comprising:
administering, to a subject to be scanned, a probe comprising a targeting region that binds only to a selected biological target and an initiator region for hybridization when the probe binds to the selected biological target;
administrating, to the subject, at least two HCR monomer components that polymerize in a chain reaction to the initiator region when the initiator region is exposed;
administrating, to the subject, at least one component comprising two conjugated different particles, each of which is made of different materials, wherein each one of the two conjugated different particles show a different response in computed tomography (CT) scan data and only a first particle remains hybridized to a polymerized HCR complex while a second particle disassociates from the polymerized HCR complex;
performing a CT scan that thereby generates the CT scan data using an imaging apparatus that detects spatial and temporal characteristics of concentrations of the two conjugated different particles; and
generating information that reflects an aggregation of the two different conjugated materials based on the CT scan data.

Assignees

• Carmi Raz
• Kafri Galit Sarit
• Koninklijke Philips Nv

Inventors

• Carmi Raz
• Kafri Galit Sarit

Classifications

• A61K49/1887

  Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix · CPC title

• A61K49/0414 Primary

  Particles, beads, capsules or spheres · CPC title

• A61B6/4014

  arranged in multiple source-detector units · CPC title

• A61K51/1244

  microparticles or nanoparticles, e.g. polymeric nanoparticles · CPC title

• A61K49/126

  Linear polymers, e.g. dextran, inulin, PEG · CPC title