Bacterial strains belonging to the genus bifidobacterium for use in the treatment of hypercholesterolaemia

Patent metadata

Field	Value
Publication number	US-9925224-B2
Application number	US-201214117003-A
Country	US
Kind code	B2
Filing date	May 9, 2012
Priority date	May 9, 2011
Publication date	Mar 27, 2018
Grant date	Mar 27, 2018

Abstract

Selected bacterial strains belonging to the genus Bifidobacterium for use in the treatment of hypercholesterolaemia are described. In particular, a food composition or supplement product or medical device or pharmaceutical composition has said bacterial strains in association with sterols or phytosterols and/or stanols or phytostanols and/or glucomannan and/or konjac gum and/or prebiotic fibers and/or fermented red rice and/or betaglucans from oats, oat bran, barley, barley bran and/or aloe arborescens gel in lyophilized form.

First claim

The invention claimed is:

1. A method for preventive or curative treatment of hypercholesterolaemia, the method comprising:
administering to a subject having hypercholesterolaemia or at a risk of developing hypercholesterolaemia a food composition or supplement product or medical device or pharmaceutical composition comprising a bacterial composition comprising:
at least one bacterial strain belonging to the species Bifidobacterium bifidum capable of absorbing cholesterol onto its surface cell wall, selected from the group consisting of bacterial strain B. bifidum BB06 (MB107) DSM 24688 and bacterial strain B. bifidum MB109 DSM 23731, and
at least one bacterial strain belonging to the species Bifidobacterium lactis, Bifidobacterium breve or Bifidobacterium infantis capable of hydrolyzing bile salts on an intracellular and/or extracellular level,

the bacterial composition in an effective amount for preventive or curative treatment of hypercholesterolaemia in the subject.

2. The method according to claim 1 , for reducing the level of LDL cholesterol in the blood.

3. The method according to claim 1 , wherein said at least one bacterial strain belonging to the species Bifidobacterium bifidum is the bacterial strain B. bifidum MB109 DSM 23731.

4. The method according to claim 1 , wherein said at least one bacterial strain belonging to the species Bifidobacterium lactis is selected from the group consisting of the bacterial strain B. lactis MB2409 DSM 23733 and the bacterial strain B. lactis BS07 (MB243) DSM 24690.

5. The method according to claim 1 , wherein said at least one bacterial strain belonging to the species Bifidobacterium breve is the bacterial strain B. breve (MB113) DSM 23732.

6. The method according to claim 1 , wherein said at least one bacterial strain belonging to the species Bifidobacterium infantis is the bacterial strain B. infantis BI02 (MB287) DSM 24687.

7. The method according to claim 1 , the bacterial composition further comprising a bacterial strain belonging to the species Bifidobacterium longum capable of producing conjugated linoleic acid (CLA) from linoleic acid (LA).

8. The method according to claim 7 , wherein said bacterial strain belonging to the species Bifidobacterium longum is Bifidobacterium longum BL04 DSM 23233.

9. The method according to claim 7 , wherein said bacterial composition consists of at least one of bacterial strain B. bifidum BB06 (MB107) DSM 24688 and bacterial strain B. bifidum MB109 DSM 23731, at least one bacterial strain belonging to the species Bifidobacterium lactis and at least one bacterial strain belonging to the species Bifidobacterium longum.

10. The method according to claim 9 , wherein:
said at least one bacterial strain belonging to the species Bifidobacterium lactis is selected from the group consisting of the bacterial strain B. lactis MB2409 DSM 23733 and the bacterial strain B. lactis BS07 (MB243) DSM 24690; and
said at least one bacterial strain belonging to the species Bifidobacterium longum is Bifidobacterium longum BL04 DSM 23233.

11. The method according to claim 1 , wherein the food composition or supplement product or medical device or pharmaceutical composition further comprises:
at least a first vegetable substance selected from the group consisting of sterols, phytosterols, stanols, phytostanols, glucomannan, and konjac gum,
at least one prebiotic fibre selected from the group comprising fructo-oligosaccharides—FOS, galacto-oligosaccharides—GOS, xylo-oligosaccharides—XOS, inulin, larch fibre and arabinogalactan, and
at least a second vegetable substance selected from the group consisting of fermented red rice, betaglucans from oats, oat bran, barley, barley bran, and aloe arborescens gel in lyophilized form.

12. The method according to claim 1 , wherein the food composition or supplement product or medical device or pharmaceutical composition further comprises:
at least a first vegetable substance selected from the group consisting of sterols, phytosterols, stanols, and phytostanols in association with at least one vegetable substance selected from the group comprising glucomannan, konjac gum, fermented red rice, betaglucans from oats, oat bran, barley, barley bran and aloe arborescens gel in lyophilized form; and
at least a second vegetable substance selected from the group consisting of sterols, phytosterols, stanols, and phytostanols in association with at least one vegetable substance selected from the group comprising glucomannan, konjac gum, fermented red rice, betaglucans from oats, oat bran, barley, barley bran and aloe arborescens gel in lyophilized form in association with at least one prebiotic fibre selected from the group comprising FOS, GOS, XOS, inulin, larch fibre and arabinogalactan.

Assignees

• Mogna Giovanni
• Strozzi Gian Paolo
• Mogna Luca
• Probiotical Spa

Inventors

• Mogna Giovanni
• Strozzi Gian Paolo
• Mogna Luca

Classifications

• A23L33/195

  Proteins from microorganisms · CPC title

• A61K35/745 Primary

  Bifidobacteria · CPC title

• A23L29/25

  Exudates, e.g. gum arabic, gum acacia, gum karaya or tragacanth · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title