Anionically modified polyallylamine derivative, use of anionically modified polyallylamine derivative as medicine, particularly for propylaxis and treatment of infections of respiratory tract caused by human metapneumovirus (hMPV), human rhinoviruses (HRV), and infection by influenza virus type A (IAV) and pharmaceutical composition comprising the anionically modified polyallylamine derivative

Patent metadata

Field	Value
Publication number	US-9925215-B1
Application number	US-201715792962-A
Country	US
Kind code	B1
Filing date	Oct 25, 2017
Priority date	Jul 29, 2014
Publication date	Mar 27, 2018
Grant date	Mar 27, 2018

Abstract

The subject of the invention is an N-sulfonic polyallylamine derivative (NSPAH) with Formula 1, wherein R is —SO 3 − or —H, and n is an integer from 150 to 15000; an application of the N-sulfonic polyallylamine derivative as a medicine, particularly for prevention and treatment of respiratory tract infections caused by the human metapneumovirus (hMPV), respiratory tract infections caused by the human rhinoviruses (HRV), and infections caused by the influenza A virus; as well as a pharmaceutical composition comprising the N-sulfonic polyallylamine derivative and application thereof.

First claim

What is claimed is:

1. A method for treating and preventing infections caused by human metapneumoviruses hMPV, respiratory tract infections caused by the human rhinoviruses (HRV) and infections caused by the influenza A virus, comprising administering the anionically modified polyallylamine derivative (NSPAH) of the

wherein each R is independently selected from —SO 3 − and —H,
at least one R is —SO 3 − group, and
n is an integer from 150 to 15000.

2. The method according to claim 1 , wherein the anionically modified polyallylamine derivative is the form of a sodium salt.

3. The method according to claim 1 , wherein the anionically modified polyallylamine derivative has the form of a solution or an aerosol administered to the upper respiratory tract.

Assignees

• Univ Jagiellonski

Inventors

• Nowakowska Maria
• Szczubialka Krzysztof
• Pyrc Krzysztof
• Ciejka Justyna
• Wytrwal Magdalena
• Milewska Aleksandra

Classifications

• C08F126/02

  by a single or double bond to nitrogen · CPC title

• A61K31/795 Primary

  Polymers containing sulfur · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title

• C08F8/36

  Sulfonation; Sulfation · CPC title

• A61K9/0073

  Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M) · CPC title