Modular intraocular lens designs, tools and methods

Patent metadata

Field	Value
Publication number	US-9925040-B2
Application number	US-201615218658-A
Country	US
Kind code	B2
Filing date	Jul 25, 2016
Priority date	Jan 24, 2012
Publication date	Mar 27, 2018
Grant date	Mar 27, 2018

Abstract

Modular IOL systems including a base and a lens, wherein the lens includes fixed and actuatable tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively. Drug delivery capabilities and/or sensing capabilities may be incorporated into the base. Injector devices may be used to facilitate placement of the base and the lens sequentially or simultaneously into the eye.

First claim

We claim:

1. An intra-ocular lens (IOL) comprising:
an optic for providing an optical correction to an eye;
a ring surrounding the optic, the ring including:
a first rim extending around the optic and disposed on a first side of the optic,
a second rim extending around the optic and disposed on a second side of the optic opposite the first side, and
a recess extending from an outer surface of the ring toward an interior of the ring, the recess including:
an open end, and
a closed end opposite the open end, wherein the open end is at the outer surface of the ring and the closed end is in the interior of the ring; and

a therapeutic agent disposed on the ring, the therapeutic agent being contained in a therapeutic agent-eluting material in the recess, for delivery of the therapeutic agent to the eye,
wherein the optic includes:
a first tab, the first tab being fixed and having a first rigidity, and
a second tab, the second tab being actuatable and having a second rigidity, wherein the first rigidity is relatively greater than the second rigidity, and wherein the second tab is actuatable between (i) a radially-compressed position, for allowing at least one of assembly of the optic to the ring and removal of the optic from the ring, and (ii) an uncompressed extended position, for interlocking of the optic and the ring.

2. The IOL of claim 1 , wherein the therapeutic agent includes a drug for treating an eye condition.

3. The IOL of claim 1 , wherein the ring includes an aperture and an outer periphery, and the recess is positioned radially-outward of the aperture and radially-inward of the outer periphery.

4. The IOL of claim 1 , wherein the first rim and the second rim establish an anterior-posterior thickness of the ring that is greater than a central thickness of the optic.

5. The IOL of claim 1 , wherein the optic defines a central visual axis, and the first rim and the second rim flare outwardly toward the central visual axis.

6. The IOL of claim 1 , wherein an inside diameter of the second rim is less than an inside diameter of the first rim.

7. The IOL of claim 1 , wherein the recess is one of a plurality of discrete recesses extending from the outer surface of the ring toward the interior of the ring.

8. The IOL of claim 7 , wherein the plurality of discrete recesses extend from only an anterior-facing outer surface of the second rim.

9. The IOL of claim 1 , wherein the therapeutic agent-eluting material is configured as a reservoir for storing the therapeutic agent.

10. The IOL of claim 1 , wherein the therapeutic agent-eluting material includes an absorbent porous material.

11. The IOL of claim 1 , further including an energy-activatable portion that releases the therapeutic agent when exposed to at least one of electromagnetic energy, thermal energy, and magnetic energy.

12. An intra-ocular lens (IOL) comprising:
an optic for providing an optical correction to an eye;
a ring surrounding the optic, the ring including:
a first portion extending around the optic and disposed on an anterior side of the optic, and
a second portion extending around the optic and disposed on a posterior side of the optic; and

a drug carrier disposed on the ring, wherein the drug carrier includes:
a recess extending from one of an anterior-facing surface of the first portion and a posterior-facing surface of the second portion, toward an interior of the ring, the recess including:
an open end, and
a closed end opposite the open end, wherein the open end is at the one of the anterior-facing surface of the first portion and the posterior-facing surface of the second portion, and the closed end is in the interior of the ring, and

a drug-eluting material in the recess configured for delivery of a drug to the eye,

wherein the optic includes:
a first tab, the first tab being fixed and having a first rigidity, and
a second tab, the second tab being actuatable and having a second rigidity, the first rigidity being relatively greater than the second rigidity, wherein the second tab is actuatable between (i) a radially-compressed position, for allowing at least one of assembly of the optic to the ring and removal of the optic from the ring, and (ii) an uncompressed extended position, for interlocking of the optic and the ring.

13. The IOL of claim 12 , wherein the drug carrier is one of a plurality of discrete drug carriers disposed on the anterior-facing surface of the first portion of the ring.

14. The IOL of claim 12 , wherein the drug-eluting material includes a porous material that absorbs the drug.

15. The IOL of claim 1 , wherein the ring includes a radially-extending cavity having a shape defined by an anterior wall, a posterior wall, and a lateral wall, the anterior wall, posterior wall, and lateral wall inhibiting relative anterior, posterior, and lateral movement between the ring and the optic.

16. The IOL of claim 1 , wherein the recess extends from an anterior-facing outer surface of the ring toward the interior of the ring.

17. The IOL of claim 1 , wherein the closed end is formed by internal material of the ring.

18. An intra-ocular lens (IOL) comprising:
an optic portion for providing an optical correction to an eye, wherein the optic portion includes:
a first tab, the first tab being fixed and having a first rigidity, and
a second tab, the second tab being actuatable and having a second rigidity, the first rigidity being relatively greater than the second rigidity;

a peripheral portion extending around an entire circumference of the optic portion; and
a drug-eluting material containing a drug, wherein:
the drug-eluting material is embedded within a plurality of recesses disposed in the peripheral portion,
each recess has an open end, and a closed end opposite the open end, and
the open ends of the plurality of recesses are at one of an anterior-facing surface of the peripheral portion and a posterior-facing surface of the peripheral portion,

wherein the second tab is actuatable between (i) a radially-compressed position, for allowing at least one of assembly of the optic portion to the peripheral portion and removal of the optic portion from the peripheral portion, and (ii) an uncompressed extended position, for interlocking of the optic portion and the peripheral portion.

19. The IOL of claim 18 , wherein the drug-eluting material includes a porous material that absorbs the drug.

20. The IOL of claim 18 , wherein the drug-eluting material in one of the plurality of recesses releases a different drug than the drug-eluting material in another of the plurality of recesses.

Assignees

• Clarvista Medical Inc
• Univ Colorado Regents

Inventors

• Kahook Malik Y
• Sussman Glenn
• Mclean Paul
• Schieber Andrew

Classifications

• A61F2002/16902

  Separable from intraocular lens · CPC title

• A61F2/1664

  for manual insertion during surgery, e.g. forceps-like instruments · CPC title

• A61F2/1613

  having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus · CPC title

• A61F2002/169

  Surrounding optic · CPC title

• A61F2/167

  with pushable plungers · CPC title