System and method for mass spectrometry imaging
US-2024389905-A1 · Nov 28, 2024 · US
US9924874B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9924874-B2 |
| Application number | US-201214356742-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 7, 2012 |
| Priority date | Nov 16, 2011 |
| Publication date | Mar 27, 2018 |
| Grant date | Mar 27, 2018 |
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A measurement device according to the present disclosure includes a light source for emitting measurement light which is used for measuring an in vivo component present in a living body and belongs to a predetermined wavelength band toward the living body, a detection unit in which a plurality of sensors is regularly arranged in a predetermined arrangement and which detects the measurement light emitted from the light source and passing through the living body with the plurality of sensors, and an analysis unit which analyzes an amount of the in vivo component based on an amount of light attenuated depending on an optical distance from the light source by use of a detection result detected by the detection unit.
Opening claim text (preview).
The invention claimed is: 1. A measurement device comprising: a body substance measurement device which measures a substance to be measured contained in a living body, the body substance measurement device having a first light source to emit light and a sensor to detect the light emitted from the first light source passing through the living body; and a correction data measurement device having (i) a second light source for emitting measurement light which is used for measuring a different in vivo component from the substance to be measured present in the living body and belongs to a predetermined wavelength band toward the living body; (ii) a detection unit in which a plurality of sensors is regularly arranged in a predetermined arrangement and which detects the measurement light emitted from the second light source and passing through the living body with the plurality of sensors; and (iii) an analysis unit which analyzes an amount of the in vivo component based on an amount of light attenuated depending on an optical distance from the second light source by use of a detection result detected by the detection unit, the body substance measurement device is configured to cause the first light source to emit the light at a first timing and the correction data measurement device is configured to cause the second light source to emit the measurement light at a second timing, in which the first timing is different from the second timing, wherein the analysis performed by the analysis unit comprises formulating a rate of light absorption by the in vivo component for light propagating inside the living body based on at least a plurality of layers of the living body and, for each layer, an indication of a number of substances in the layer. 2. The measurement device according to claim 1 , wherein the analysis unit models subcutaneous tissues of the living body and analyzes the detection result as a linear sum of absorption by the in vivo component of interest, thereby calculating the amount of the in vivo component. 3. The measurement device according to claim 2 , wherein the detection unit detects measurement light passing through the living body by a second sensor utilizing a micro lens array in which a plurality of lenses is regularly arranged in a grid shape. 4. The measurement device according to claim 1 , wherein the analysis unit calculates at least any of an amount of any of melanin, blood component, and water as the in vivo component. 5. The measurement device according to claim 4 , wherein the analysis unit further calculates at least any of the amount of blood, a thickness of fat, and a thickness of the dermic layer. 6. The measurement device according to claim 1 , wherein the body substance measurement device or the analysis unit corrects a measurement result in the body substance measurement device by use of the amount of the in vivo component. 7. A measurement method for use with a measurement device having a body substance measurement device and a correction data measurement device, said method comprising: measuring, by use of the body substance measurement device, a substance to be measured contained in a living body by emitting light from a first light source of the body substance measurement device and detecting the light emitted from the first light source passing through the living body by a sensor of the body substance measurement device; and using the correction data measurement device to (i) cause a second light source to emit measurement light for measuring a different in vivo component from the substance to be measured present in the living body and having a predetermined wavelength band toward the living body; (ii) detect the measurement light emitted from the second light source and passing through the living body with a plurality of sensors regularly arranged in a predetermined arrangement; and (iii) analyze an amount of the in vivo component based on an amount of light attenuated depending on an optical distance from the second light source by use of a detection result detected by the detection unit, in which the first light source is caused to emit the light at a first timing and the second light source is caused to emit the measurement light at a second timing, in which the first timing is different from the second timing, wherein using the correction data measurement device to analyze comprises formulating a rate of light absorption by the in vivo component for light propagating inside the living body based on at least a plurality of layers of the living body and, for each layer, an indication of a number of substances in the layer. 8. A non-transitory computer readable storage medium having stored thereon a program for causing a computer to control a measurement device having a body substance measurement device and a correction data measurement device to perform a method, said method comprising: measuring, by use of the body substance measurement device, a substance to be measured contained in a living body by emitting light from a first light source of the body substance measurement device and detecting the light emitted from the first light source passing through the living body by a sensor of the body substance measurement device; and using the correction data measurement device to (i) cause a second light source to emit measurement light for measuring a different in vivo component from the substance to be measured present in the living body and having a predetermined wavelength band toward the living body; (ii) detect the measurement light emitted from the second light source and passing through the living body with a plurality of sensors regularly arranged in a predetermined arrangement; and (iii) analyze an amount of the in vivo component based on an amount of light attenuated depending on an optical distance from the second light source by use of a detection result detected by the detection unit, in which the first light source is caused to emit the light at a first timing and the second light source is caused to emit the measurement light at a second timing, in which the first timing is different from the second timing, wherein using the correction data measurement device to analyze comprises formulating a rate of light absorption by the in vivo component for light propagating inside the living body based on at least a plurality of layers of the living body and, for each layer, an indication of a number of substances in the layer.
by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title
for measuring blood gases (A61B5/14551 takes precedence) · CPC title
Evaluating skin constituents, e.g. elastin, melanin, water · CPC title
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