Needle-shaped body and method for manufacturing needle-shaped body

Patent metadata

Field	Value
Publication number	US-9919141-B2
Application number	US-201414579490-A
Country	US
Kind code	B2
Filing date	Dec 22, 2014
Priority date	Jun 22, 2012
Publication date	Mar 20, 2018
Grant date	Mar 20, 2018

Abstract

A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body.

First claim

The invention claimed is:

1. A needle-shaped body, comprising:
a needle-shaped projection; and
a support base which supports the needle-shaped projection,
wherein at least a portion of the needle-shaped projection comprises a projection side layer, at least a portion of the support base comprises a support base side layer, the projection side layer is formed directly on the support base side layer, and the needle-shaped projection and the support base comprise different materials such that peeling strength between the projection side layer and the support base side layer is 8 N/15 mm in width or lower.

2. The needle-shaped body according to claim 1 , wherein the support base side layer and a portion of the projection side layer form the support base.

3. The needle-shaped body according to claim 2 , wherein the portion of the projection side layer in the support base has a smaller area than an outer shape of the support base.

4. The needle-shaped body according to claim 1 , wherein the projection side layer and a portion of the support base side layer form the needle-shaped projection.

5. The needle-shaped body according to claim 1 , wherein the projection side layer and the support base side layer are formed such that a boundary of the projection side layer and the support base side layer is located in a joint portion of the needle-shaped projection and the support base.

6. A needle-shaped body, comprising:
a needle-shaped projection; and
a support base which supports the needle-shaped projection,
wherein at least a portion of the needle-shaped projection comprises a projection side layer, at least a portion of the support base comprises a support base side layer, the projection side layer is formed directly on the support base side layer, the projection side layer comprises at least one material selected from the group consisting of pullulan and dextran, and the support base side layer comprises at least one material selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, and hydroxypropyl methyl cellulose.

7. The needle-shaped body according to claim 6 , wherein the support base side layer and a portion of the projection side layer form the support base.

8. The needle-shaped body according to claim 7 , wherein the portion of the projection side layer in the support base has a smaller area than an outer shape of the support base.

9. The needle-shaped body according to claim 6 , wherein the projection side layer and a portion of the support base side layer form the needle-shaped projection.

10. The needle-shaped body according to claim 6 , wherein the projection side layer and the support base side layer are formed such that a boundary of the projection side layer and the support base side layer is located in a joint portion of the needle-shaped projection and the support base.

11. The needle-shaped body according to claim 6 , wherein the projection side layer comprises the at least one material selected from the group consisting of pullulan and dextran and the support base side layer comprises the at least one material selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose and hydroxypropyl methyl cellulose such that peeling strength between the projection side layer and the support base side layer is 8 N/15 mm in width or lower.

Assignees

• Toppan Printing Co Ltd

Inventors

• Tagami Hanae
• Kato Hiroyuki

Classifications

• A61M2037/0053

  Methods for producing microneedles · CPC title

• A61M2037/0046

  Solid microneedles · CPC title

• A61M37/0015 Primary

  by using microneedles · CPC title

• A61K9/0021

  Intradermal administration, e.g. through microneedle arrays or needleless injectors · CPC title

• A61K9/0014

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title