Selective production method for D-mannitol α-form crystal using spray-drying method

US9918938B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-9918938-B2
Application numberUS-201415024622-A
CountryUS
Kind codeB2
Filing dateSep 29, 2014
Priority dateSep 30, 2013
Publication dateMar 20, 2018
Grant dateMar 20, 2018

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  1. Title

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  2. Abstract

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  5. First independent claim

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Abstract

Official abstract text for this publication.

An object of the present invention is to provide a method for producing selectively a powder particle consisting of the α-form crystal of D-mannitol, using the spray-drying method. It is a method for selective production of powder particles consisting of the α-form crystal of D-mannitol, wherein a D-mannitol solution containing a water-soluble polymer is spray-dried.

First claim

Opening claim text (preview).

The invention claimed is: 1. A method for producing selectively an α-form crystal of D-mannitol, comprising a step of performing spray drying of a solution consisting essentially of D-mannitol and a water-soluble polymer, wherein the solution is a mixture solution of a water-soluble organic solvent and water or an aqueous solution, wherein the water-soluble polymer is pectin, carboxyvinyl polymer, brown algae extract, locust bean gum, sodium alginate, hydroxyethyl cellulose, hydroxypropyl cellulose, hypromellose, methyl cellulose, sodium carboxy methylcellulose, xanthan gum, polyethylene oxide, polyethylene glycol, polyvinyl pyrrolidone, polyvinyl alcohol, or polyvinyl pyrrolidone vinylacetate, wherein the content of the water-soluble polymer in the solution is 1% to 60% by weight with respect to D-mannitol. 2. The method according to claim 1 , wherein the water-soluble organic solvent is a C1 to C6 alcohol-based solvent or a C3 to C5 ketone-based solvent. 3. The method according to claim 1 , wherein the water-soluble polymer is polyethylene glycol, polyvinyl pyrrolidone, or polyvinyl alcohol. 4. The method according to claim 1 , wherein the water-soluble polymer is polyethylene glycol. 5. The method according to claim 1 , wherein the molecular weight of the water-soluble polymer is 190 g/mol to 25000 g/mol. 6. The method according to claim 1 , wherein the water-soluble polymer is polyethylene glycol 4000. 7. The method according to claim 1 , wherein the content of the water-soluble polymer in the solution is 2% by weight or more with respect to D-mannitol. 8. The method according to claim 1 , wherein the content of the water-soluble polymer in the solution is 5% by weight or more with respect to D-mannitol. 9. The method according to claim 1 , wherein the content of the water-soluble polymer in the solution is 10% by weight or more with respect to D-mannitol.

Assignees

Inventors

Classifications

  • by condensation or crystallisation · CPC title

  • Processes · CPC title

  • C07C29/76Primary

    by physical treatment · CPC title

  • Hexahydroxylic alcohols · CPC title

  • obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers · CPC title

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What does patent US9918938B2 cover?
An object of the present invention is to provide a method for producing selectively a powder particle consisting of the α-form crystal of D-mannitol, using the spray-drying method. It is a method for selective production of powder particles consisting of the α-form crystal of D-mannitol, wherein a D-mannitol solution containing a water-soluble polymer is spray-dried.
Who is the assignee on this patent?
Daiichi Sankyo Co Ltd
What technology area does this patent fall under?
Primary CPC classification C07C29/76. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Mar 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).