Radiopharmaceutical administration methods, fluid delivery systems and components thereof

Patent metadata

Field	Value
Publication number	US-9913941-B2
Application number	US-201514736949-A
Country	US
Kind code	B2
Filing date	Jun 11, 2015
Priority date	Jan 1, 2007
Publication date	Mar 13, 2018
Grant date	Mar 13, 2018

Abstract

A fluid path set for a fluid delivery system includes a tube coil that is designed to optimally position one or more volumes of a pharmaceutical within an ionization chamber to measure and prepare a pharmaceutical dose for administration to a patient. Methods for priming at least a portion of the fluid path set include placing a tubing section of the fluid path set in fluid connection with a source of a radiopharmaceutical, and placing the tube coil within a dose calibrator of the fluid delivery system. A volume of the radiopharmaceutical may be pumped through the tube coil, the tubing section, and an additional tubing section, and the dose calibrator may be monitored to determine if a measured activity level is substantially equal to or above a predetermined activity level, and if so, it may be concluded that the tubing section of the fluid path set has been primed.

First claim

What is claimed is:

1. A method of priming at least a portion of a fluid path set in a fluid delivery system, the method comprising:
placing a second tubing section of the fluid path set in fluid connection with a source of a radiopharmaceutical;
placing a coil tubing section within a dose calibrator of the fluid delivery system;
pumping a volume of the radiopharmaceutical through the second tubing section, a third tubing section, and the coil tubing section, wherein the third tubing section is located between a first T-connector in fluid communication with the second tubing section and the coil tubing section;
monitoring the dose calibrator to determine if a measured activity level is substantially equal to or above a predetermined activity level; and
if the measured activity level is substantially equal to or above the predetermined activity level, then concluding that the second tubing section of the fluid path set has been primed.

2. The method of claim 1 , further comprising:
if the measured activity level is zero or below the predetermined activity level, then concluding that the second tubing section of the fluid path has not been primed; and
pumping a second volume of the radiopharmaceutical through the second tubing section.

3. The method of claim 1 , further comprising:
placing a first tubing section in fluid connection with a source of a medical fluid and the third tubing section by way of the T-connector; and
pumping a volume of the medical fluid through the first tubing section and at least a portion of the third tubing section to move the volume of the radiopharmaceutical to the portion of the coil tubing section that is positioned within the dose calibrator.

4. The method of claim 3 , further comprising:
placing the third tubing section and the coil tubing section in fluid connection with a waste receptacle by way of a fourth tubing section, a second T-connector, and a fifth tubing section; and
pumping a second volume of the medical fluid through the first tubing section and at least a portion of the third tubing section and the coil tubing section to move the volume of the radiopharmaceutical into the waste receptacle.

5. The method of claim 3 , wherein the source of medical fluid is a source of saline.

6. The method of claim 4 , further comprising:
placing a sixth tubing section in fluid connection with the first tubing section, wherein the sixth tubing section is in fluid communication with a single-patient fluid path set; and
pumping a third volume of the medical fluid through the sixth tubing section to prime the single-patient fluid path set.

7. The method of claim 6 , further comprising indicating to an operator that the fluid delivery system and the single-patient fluid path set are primed and ready for an injection procedure.

8. The method of claim 7 , further comprising connecting the single-patient fluid path set to a vasculature of a patient.

9. The method of claim 1 , wherein the portion of the coil tubing section within the dose calibrator comprises a tube coil of a coil assembly component.

10. The method of claim 9 , wherein the tube coil has an outer diameter of approximately 0.218 inches, an inner diameter of approximately 0.156 inches, and a length of approximately 41 inches.

11. A method of priming a multi-patient fluid path set in a fluid delivery system, the method comprising:
placing a second tubing section of the fluid path set in fluid connection with a source of a radiopharmaceutical, wherein the second tubing section comprises a portion of the multi-patient fluid path set;
placing a portion of a coil tubing section within a dose calibrator of the fluid delivery system;
placing a first tubing section in fluid connection with a source of medical fluid and the first tubing section;
pumping a volume of the radiopharmaceutical into the second tubing section, a third tubing section, and the coil tubing section, wherein the third tubing section is located between a first T-connector in fluid communication with the second tubing section and the coil tubing section;
pumping a volume of the medical fluid through the first tubing section and at least a portion of the third tubing section to move the volume of the radiopharmaceutical to the portion of the coil tubing section that is positioned within the dose calibrator;
monitoring the dose calibrator to determine if a measured activity level is substantially equal to or above a predetermined activity level;
if the measured activity level is substantially equal to or above the predetermined activity level, then concluding that the second tubing section of the fluid path set has been primed; and
if the measured activity level is zero or below the predetermined activity level, then concluding that the second tubing section of the fluid path has not been primed and repeating the pumping steps and monitoring steps to determine if the second tubing section of the fluid path set has been primed.

12. The method of claim 11 , further comprising:
placing the third tubing section and the coil tubing section in fluid connection with a waste receptacle by way of a fourth tubing section, a second T-connector, and a fifth tubing section; and
pumping a second volume of the medical fluid through the first tubing section and at least a portion of the third tubing section and the coil tubing section to move the volume of the radiopharmaceutical into the waste receptacle.

13. The method of claim 12 , further comprising:
placing a sixth tubing section in fluid connection with the first tubing section, wherein the sixth tubing section is in fluid communication with a single-patient fluid path set; and
pumping a third volume of the medical fluid through the sixth tubing section to prime the single-patient fluid path set.

14. The method of claim 13 , further comprising:
indicating to an operator that the multi-patient fluid path set and the single-patient fluid path set are primed and ready for an injection procedure.

15. The method of claim 14 , further comprising connecting the single-patient fluid path set to a vasculature of a patient.

Assignees

• Bayer Medical Care Inc
• Bayer Healthcare Llc

Inventors

• Miller Paul J
• Shigeno James H
• Neff Jared E
• Tate Leon J
• Bisegna Joseph E
• Ilgenfritz Edward
• Griffith Scott R
• Ripley Brandon

Classifications

• A61K51/00

  Preparations containing radioactive substances for use in therapy or testing in vivo · CPC title

• A61M5/172 Primary

  electrical or electronic {(A61M5/16804, A61M5/16831 take precedence)} · CPC title

• A61M5/007

  for contrast media · CPC title

• G06F19/3468

  Physics · mapped topic

• A61M5/14

  Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor · CPC title