Methods and compositions for treating melanoma
US-2024424002-A1 · Dec 26, 2024 · US
Combination therapy
US9913844B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9913844-B2 |
| Application number | US-201414777873-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 19, 2014 |
| Priority date | Mar 21, 2013 |
| Publication date | Mar 13, 2018 |
| Grant date | Mar 13, 2018 |
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Abstract
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Reversing resistance to a B-Raf inhibitor for the treatment of a proliferative disease by obtaining a tumor sample from the patient and testing it for genetic alterations in a panel of genes comprising BRAF, CRAF, CCND1, CDK4, HER2, IGF-1R, cMET, FGFR1, FGFR2, FGFR3 EGFR, MAP2K1, MAP2K2, NRAS, KRAS HRAS, PTEN, PIK3CA, and P16 and administering a drug combination therapy comprising the B-Raf inhibitor and a second inhibitor which overcomes resistance to the B-Raf inhibitor, which second inhibitor is selected based on genetic alterations discovered in the tumor sample.
First claim
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The invention claimed is: 1. A therapeutic combination consisting essentially of a B-Raf inhibitor of Formula (I) or a pharmaceutically acceptable salt thereof; and a second inhibitor which is a PI3 kinase inhibitor of 5-(2,6-di-morpholin-4-yl-pyrimidin-4-yl)-4-trifluoromethyl-pyridin-2-ylamine (Compound F) or (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) (Compound X), or a pharmaceutically acceptable salt thereof, for separate, simultaneous or sequential administration. 2. The therapeutic combination of claim 1 , wherein the PI3 kinase inhibitor is 5-(2,6-di-morpholin-4-yl-pyrimidin-4-yl)-4-trifluoromethyl-pyridin-2-ylamine (Compound F), or a pharmaceutically acceptable salt thereof. 3. The therapeutic combination of claim 1 , wherein the PI3 kinase inhibitor is (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) (Compound X), or a pharmaceutically acceptable salt thereof.
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- What does patent US9913844B2 cover?
- Reversing resistance to a B-Raf inhibitor for the treatment of a proliferative disease by obtaining a tumor sample from the patient and testing it for genetic alterations in a panel of genes comprising BRAF, CRAF, CCND1, CDK4, HER2, IGF-1R, cMET, FGFR1, FGFR2, FGFR3 EGFR, MAP2K1, MAP2K2, NRAS, KRAS HRAS, PTEN, PIK3CA, and P16 and administering a drug combination therapy comprising the B-Raf inh…
- Who is the assignee on this patent?
- Novartis Ag
- What technology area does this patent fall under?
- Primary CPC classification A61K31/506. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).