System and method for processing samples

Patent metadata

Field	Value
Publication number	US-9910054-B2
Application number	US-201214356347-A
Country	US
Kind code	B2
Filing date	Nov 7, 2012
Priority date	Nov 7, 2011
Publication date	Mar 6, 2018
Grant date	Mar 6, 2018

Abstract

An analytical laboratory system and method for processing samples is disclosed. The system includes a manager unit, as well as an aliquotter unit and a centrifuge unit.

First claim

What is claimed is:

1. A method of handling a sample container within a laboratory automation system, comprising:
gripping a sample container positioned in an input module for transport from said input module to a distribution area with a first gripper;
detecting information about the sample container with an instrument associated with the first gripper, which information includes determining a level of one or more liquids of a sample in said sample container and capturing an image of said sample container; and
transporting with the first gripper the sample container from said input module to said distribution area;
gripping the sample container positioned in the distribution area with a second gripper;
transporting with the second gripper the sample container from the distribution area to at least one of a centrifuge adapter, a carrier on a conveyance system, and an error area;
requesting a sample schedule associated with the sample in the sample container, wherein the sample schedule is requested from a scheduling system based on:
data obtained by detecting information step, and
test information associated with the sample; and

determining, by the scheduling system, a time when the sample container containing the sample should be removed from the distribution area for further processing;
determining whether an error is associated with the sample;
when an error is associated with the sample, transporting the sample container to an error area; and
when no error is associated with the sample, transporting the sample container, based on the obtained sample schedule, via a second gripper, from the distribution area to a subsequent processing module in the laboratory automation system at the time determined by the scheduling system, wherein:
when the subsequent processing module is a centrifuge unit having a centrifuge rotor, placing the sample container by said second gripper into an adapter of a centrifuge based upon calculated estimate of a total sample container weight for balance of the centrifuge rotor and/or based on a sample priority; and
when the subsequent processing module is not a centrifuge unit, transporting the sample container, by said second gripper, into a carrier on a conveyance system.

2. The method of claim 1 , wherein, during the transporting of the sample container, the level of the one or more liquids of the sample are measured and an image of the sample container is captured.

3. The method of claim 1 , wherein, based on the determined level of the one or more liquids, volumes of one or more components of the sample are determined.

4. The method of claim 1 , wherein detecting information includes the use of an emitter and a receiver, wherein the emitter and the receiver are used for a measurement to determine one or more liquid levels of the sample.

5. The method of claim 1 , further comprising analyzing the captured image to determine at least one of a manufacturer of the sample container, a diameter of the sample container, a height of the sample container, a color of a sample container cap, a shape of the sample container cap, a presence of a marker and a presence of a label.

6. The method of claim 5 , further comprising calculating an estimate of a total sample container weight based on:
the determined level of the one or more liquids of the sample, and
the analysis of the captured image.

7. The method of claim 1 wherein, if the subsequent processing module is a centrifuge unit:
transporting, by a shuttle, the centrifuge adapter from the distribution area to the centrifuge unit, and
transferring, by a third gripper, the centrifuge adapter to a bucket of the centrifuge.

8. A laboratory automation system for handling sample containers, comprising:
an input module configured to receive sample containers into the laboratory automation system;
a distribution area, configured as a holding area for the sample containers;
a first gripper, for gripping the sample container from the input module and transporting a sample container to the distribution area;
an instrument associated with said first gripper for detecting information about the sample container, wherein the information includes one or more liquid levels of a sample contained in the sample container and an image of the sample container;
a conveyance system;
an error area;
at least one centrifuge adapter;
a scheduling system for determining a sample schedule associated with the sample, wherein the sample schedule is based at least in part on:
the information obtained by the instrument for detecting information, and
test information associated with the sample; and

a second gripper, configured to transport the sample container from the distribution area to at least one of the centrifuge adapter, a carrier on the conveyance system, and the error area, wherein the second gripper transports the sample container at a time determined using the sample schedule.

9. The laboratory automation system of claim 8 , wherein the information detecting instrument is capable of, during the transport of the sample container from the input module to the distribution area:
determining one or more liquid levels of the sample, and
capturing at least one image of the sample container.

10. The laboratory automation system of claim 8 , wherein:
the information detecting instrument includes an emitter and a receiver for determining the one or more liquid levels of said sample; and
the emitter and the receiver are used for a measurement to determine one or more liquid levels of the sample.

11. The laboratory automation system of claim 8 , further comprising:
a centrifuge unit including a centrifuge; and
a centrifuge adapter shuttle that transports centrifuge adapters between the distribution area and the centrifuge unit.

12. The laboratory automation system of claim 11 , further comprising a third gripper that transfers centrifuge adapters to and from a bucket of the centrifuge.

Assignees

• Beckman Coulter Inc

Inventors

• Johns Charles W

Classifications

• G01M1/14

  Determining imbalance (G01M1/30 takes precedence) · CPC title

• G01F23/292

  Light {, e.g. infrared or ultraviolet} · CPC title

• G01N2035/1032

  Dilution or aliquotting · CPC title

• G01N2035/1025

  Fluid level sensing · CPC title

• G01N2035/0491

  Position sensing, encoding; closed-loop control · CPC title