Sensor device for detecting an analyte

Patent metadata

Field	Value
Publication number	US-9910007-B2
Application number	US-201314087347-A
Country	US
Kind code	B2
Filing date	Nov 22, 2013
Priority date	May 23, 2011
Publication date	Mar 6, 2018
Grant date	Mar 6, 2018

Abstract

A sensor device for detecting at least one analyte in a fluid, in particular in a body fluid, is disclosed. The sensor device includes at least one closed detector chamber and at least one electrical sensor having at least one sensor electrode. The detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber. The detector chamber includes at least one detector substance. The detector substance is designed to influence at least one electrical property of the electrical sensor, in particular at least one electrical property of the sensor electrode, depending on a concentration of the analyte in the detector chamber.

First claim

The invention claimed is:

1. A sensor device for detecting at least one analyte in a fluid, comprising at least one closed detector chamber and at least one electrical sensor comprising at least one sensor electrode, wherein the detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber, wherein the detector chamber comprises at least one detector substance, wherein the detector substance is configured to influence at least one electrical property of the electrical sensor, depending on a concentration of the analyte in the detector chamber, wherein the detector chamber accommodates at least one receptor, the receptor being formed by a substance distinct from the detector substance and wherein the receptor is configured to bind the analyte reversibly; and
wherein the detector chamber comprises at least one membrane, wherein the membrane is configured to enable the analyte to penetrate into the detector chamber reversibly and wherein the membrane is configured to retain the at least one detector substance in the detector chamber.

2. The sensor device of claim 1 , wherein the detector substance comprises electrically charged particles.

3. The sensor device of claim 2 , wherein the detector chamber and the detector substance are configured in such a way that an average distance between the electrically charged particles and the sensor electrode and/or a charge distribution within the detector chamber are dependent on a concentration of the analyte in the detector chamber.

4. The sensor device of claim 2 , wherein the detector substance furthermore comprises at least one spacer, wherein the spacer is designed to bind the electrically charged particles to the sensor electrode and/or a surface of the detector chamber at the sensor electrode, wherein the spacer is designed to assume at least two positions in which the electrically charged particles are at different distances from the sensor electrode.

5. The sensor device of claim 1 , wherein the detector substance is configured in such a way that dielectric properties of the detector substance are dependent on a concentration of the analyte in the detector chamber.

6. The sensor device of claim 1 , wherein the receptor is an immobilized receptor.

7. The sensor device of claim 6 , wherein the receptor is a receptor immobilized at the sensor electrode and/or at a surface of the detector chamber at the sensor electrode.

8. The sensor device of claim 1 , wherein the electrical sensor further comprises at least one counterelectrode in addition to the sensor electrode, wherein the sensor device is configured to apply at least one electrical potential to the counterelectrode.

9. The sensor device of claim 1 , wherein the sensor device further comprises at least one compensation sensor.

10. The sensor device of claim 1 , wherein the electrical sensor comprises at least one field effect transistor, wherein the sensor electrode comprises at least one gate electrode of the field effect transistor.

11. The sensor device of claim 10 , wherein the field effect transistor is an organic field effect transistor.

12. The sensor device of claim 1 , wherein the sensor device further comprises at least one driving unit, wherein the driving unit is designed to detect the at least one electrical property of the electrical sensor.

13. The sensor device of claim 1 , wherein the electrical sensor comprises at least one organic conductive or semiconducting material.

14. The sensor device of claim 13 , wherein the sensor electrode comprises the at least one organic conductive or semiconducting material.

15. The sensor device of claim 13 , wherein the organic conductive or semiconducting material is a conductive or semiconducting polymer.

16. A sensor system comprising the sensor device of claim 1 , and at least one reader, wherein the sensor device and the reader are configured to communicate with one another.

17. The sensor system of claim 16 , wherein the sensor device and the reader are configured to communicate wirelessly.

18. A method for detecting at least one analyte in a fluid, using the sensor device of claim 1 , comprising:
connecting the detector chamber with the fluid in such a way that the analyte penetrates into the detector chamber; influencing at least one electrical property of the electrical sensor with the detector substance wherein the level of influence on the at least one electrical property is based upon a concentration of the analyte in the detector chamber; and
reversibly binding the analyte with the receptor.

19. A sensor device for detecting at least one analyte in a fluid, comprising at least one closed detector chamber and at least one electrical sensor comprising at least one sensor electrode, wherein the detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber, wherein the detector chamber comprises at least one detector substance, wherein the detector substance is configured to influence at least one electrical property of the electrical sensor, depending on a concentration of the analyte in the detector chamber, wherein the detector chamber accommodates at least one receptor, the receptor being formed by a substance distinct from the detector substance and wherein the receptor is configured to bind the analyte reversibly; and
wherein the detector substance comprises at least one detection reagent, wherein the detection reagent is configured to react with the analyte.

20. The sensor device of claim 19 , wherein the detector substance comprises at least one enzyme.

21. A sensor device for detecting at least one analyte in a fluid, comprising at least one closed detector chamber and at least one electrical sensor comprising at least one sensor electrode, wherein the detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber, wherein the detector chamber comprises at least one detector substance, wherein the detector substance is configured to influence at least one electrical property of the electrical sensor, depending on a concentration of the analyte in the detector chamber, wherein the detector chamber accommodates at least one receptor, the receptor being formed by a substance distinct from the detector substance and wherein the receptor is configured to bind the analyte reversibly; and
wherein the sensor device further comprises at least one compensation sensor and wherein the compensation sensor comprises at least one compensation sensor electrode, wherein the detector substance is connected to the sensor electrode, wherein the compensation sensor electrode is free of the detector substance.

22. A sensor device for detecting at least one analyte in a fluid, comprising at least one closed detector chamber and at least one electrical sensor comprising at least one sensor electrode, wherein the detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber, wherein the detector chamber comprises at least one detector substance, wherein the detector substance is configured to influence at least one electrical property of the electrical sensor, depending on a concentration of the analyte in the detector chamber, wherein the detector chamber accommodates at least one receptor, the receptor being formed by a substance distinct from the detector substance and wherein the receptor is configured to bind the analyte reve

Assignees

• Roche Diabetes Care Inc

Inventors

• Fuerst Otto
• Pill Johannes
• Roesicke Bernd

Classifications

• A61B5/14735

  comprising an immobilised reagent · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• G01N27/403

  Cells and electrode assemblies · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• G01N27/4145

  specially adapted for biomolecules, e.g. gate electrode with immobilised receptors · CPC title