Therapeutic compounds

Patent metadata

Field	Value
Publication number	US-9908856-B2
Application number	US-201515121324-A
Country	US
Kind code	B2
Filing date	Feb 26, 2015
Priority date	Feb 26, 2014
Publication date	Mar 6, 2018
Grant date	Mar 6, 2018

Abstract

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

First claim

What is claimed is:

1. A compound of formulae II:

wherein:
X is N, Y is CH and Z is N;
X is N, Y is CH and Z is CH;
X is N, Y is N and Z is CH;
X is CH, Y is CH and Z is CH;
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br; wherein the ring containing X, Y, and Z is optionally substituted on carbon with one or more groups independently selected from halo;
or a salt thereof
provided the compound is not:

2. The compound of claim 1 which is a compound of formulae IIa, IIb, or IIc:

wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a salt thereof.

3. The compound of claim 1 which is a compound of formulae IIa or IIc:

wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a salt thereof.

4. The compound of claim 1 which is a compound of formulae IIc:

wherein:
R 2 is H or methyl; and
R 3 is ethyl that is optionally substituted with one or more groups independently selected from F, Cl, and Br;
or a salt thereof.

5. A compound selected from:

or a salt thereof.

6. A compound selected from:

or a salt thereof.

7. The compound,

or a salt thereof.

8. A compound selected from the group consisting of:

or a salt thereof.

9. A compound selected from the group consisting of:

or a salt thereof.

Assignees

• Univ Arizona State

Inventors

• Wagner Carl
• Marshall Pamela
• Jurutka Peter

Classifications

• C07D235/10

  Radicals substituted by halogen atoms or nitro radicals · CPC title

• C07D213/48

  Aldehydo radicals · CPC title

• C07D239/42

  One nitrogen atom (nitro radicals C07D239/30) · CPC title

• C07D241/28

  in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms · CPC title

• C07D333/54

  with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring · CPC title