Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid
US-9309195-B2 · Apr 12, 2016 · US
US9908850B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9908850-B2 |
| Application number | US-201715468419-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 24, 2017 |
| Priority date | May 5, 2004 |
| Publication date | Mar 6, 2018 |
| Grant date | Mar 6, 2018 |
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Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.
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What is claimed is: 1. An atorvastatin piperazine having an x-ray powder diffraction pattern containing the following 2θ peaks measured using CuKαradiation: 7.8, 9.3, 11.8, 16.1, and 19.7. 2. An atorvastatin piperazine having an x-ray powder diffraction pattern containing the following 2θ peaks measured using CuKα radiation: 4.4, 7.8, 9.3, 11.8, 13.2, 16.1, 17.7, 19.7, 20.4, 22.2, 22.9, 23.8 and 26.4.
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for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title
for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis · CPC title
for osteoporosis · CPC title
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