Method for preparation of filaments of poly(α-lipoic acid) polymers

Patent metadata

Field	Value
Publication number	US-9907815-B2
Application number	US-201414549661-A
Country	US
Kind code	B2
Filing date	Nov 21, 2014
Priority date	Nov 21, 2013
Publication date	Mar 6, 2018
Grant date	Mar 6, 2018

Abstract

A method for the polymerization of α-lipoic acid and α-lipoic acid derivatives includes preparing an α-lipoic formulation, exposing the α-lipoic formulation to an aqueous phase and a gaseous phase at a gas/water interface, and allowing the α-lipoic formulation to polymerize at the gas/water interface to form a poly(α-lipoic acid) polymer. The α-lipoic formulation can be an α-lipoic solution of an α-lipoic solute and an organic solvent miscible with water, and can also be an α-lipoic acid or oligomer or polymer thereof in liquid (typically melt) form.

First claim

What is claimed is:

1. A method of forming filaments from the polymerization of α-lipoic acid, the method comprising:
providing a liquid α-lipoic formulation in the form of a solution of α-lipoic acids dissolved in an organic solvent miscible with water,
exposing said liquid α-lipoic formulation to an aqueous phase and a gaseous phase at a gas/water interface;
allowing the liquid α-lipoic formulation to polymerize in light of being present at the gas/water interface to form a poly(α-lipoic acid) polymer; and
forming filaments by pulling filaments of said poly(α-lipoic acid) polymer formed at said gas/water interface.

2. The method of claim 1 , wherein said organic solvent is selected from ethanol, isopropanol, methanol, acetone, glycerin, propylene glycol, tetraethylene glycol, dioxane, dimethylsulfoxide and tetrahydrofuran.

3. The method of claim 1 , wherein the liquid α-lipoic formulation further includes a non-water soluble compound.

4. A method of claim 3 , wherein the non-water soluble compound is selected from a therapeutic agent and a crosslinking agent.

5. The method of claim 1 , wherein the aqueous phase contains a water-soluble compound.

6. The method of claim 5 , wherein the water soluble compound is a therapeutic agent.

7. The method of claim 1 , wherein the gaseous phase is selected from air, an inert gas, and pure oxygen.

8. The method of claim 1 , wherein, in said step of exposing, said liquid α-lipoic formulation is deposited onto water.

9. The method of claim 8 , wherein, in said step of exposing, the liquid α-lipoic formulation is deposited onto a substrate surface having water thereon.

10. The method of claim 1 , wherein, in said step of exposing, the liquid α-lipoic formulation is electrosprayed or electrospun onto a gas/water interface.

11. A polymerization method for forming filaments comprising:
providing a liquid formulation consisting of α-lipoic acid dissolved in an organic solvent miscible with water,
exposing the liquid formulation to an aqueous phase and a gaseous phase at a gas/water interface;
allowing the exposed liquid formulation to polymerize to form a polymer comprising poly(α-lipoic acid), where the polymerization occurs in light of being present at the gas/water interface; and
forming filaments by pulling filaments of the polymer formed at the gas/water interface.

Assignees

• Puskas Judit E
• Rosenthal Kim Emily Q
• Univ Akron

Inventors

• Puskas Judit E
• Rosenthal Kim Emily Q

Classifications

• A61K31/385

  having two or more sulfur atoms in the same ring · CPC title

• A61K31/795 Primary

  Polymers containing sulfur · CPC title