Delivery system for ocular implant

Patent metadata

Field	Value
Publication number	US-9907697-B2
Application number	US-201615005745-A
Country	US
Kind code	B2
Filing date	Jan 25, 2016
Priority date	Apr 24, 2012
Publication date	Mar 6, 2018
Grant date	Mar 6, 2018

Abstract

A delivery system is disclosed which can be used to deliver an ocular implant into a target location within the eye via an ab interno procedure. In some embodiments, the implant can provide fluid communication between the anterior chamber and the suprachoroidal or supraciliary space while in an implanted state. The delivery system can include a proximal handle component and a distal delivery component. In addition, the proximal handle component can include an actuator to control the release of the implant from the delivery component into the target location in the eye.

First claim

The invention claimed is:

1. An eye treatment system, comprising:
delivery system for delivering an ocular implant into an eye, the delivery system comprising:
a) a proximal handle portion;
b) a delivery portion coupled to the handle portion, the delivery portion configured to releasably couple to an ocular implant, the delivery portion including a retractable guidewire that fits through an inner lumen of the ocular implant such that only the guidewire is inserted through the inner lumen of the ocular implant when the ocular implant is attached to the guidewire;
c) wherein the guidewire includes at least one non-spiraled curved section for providing an interference fit between the guidewire and an inner lumen of the ocular implant when the ocular implant is mounted on the guidewire to assist in retaining the implant on the guidewire during delivery into the eye, wherein the curved section of the guidewire is confined along a discrete section of the guidewire such that the discrete section of the guidewire forms a radius of curvature that is tighter than a radius of curvature of the entire guidewire and wherein the guidewire comprises at least two curved sections, the curved sections being spaced from one another a distance of about 0.0100 inch to 0.0200 inch along the length of the guidewire;
d) an actuator that actuates to cause an ocular implant coupled to the delivery portion to release from the delivery portion upon actuation of the actuator; and

the ocular implant.

2. The eye treatment system of claim 1 , wherein the delivery portion further includes a sheath positioned axially over at least a portion of the guidewire.

3. The eye treatment system of claim 2 , wherein the actuator includes a mechanism that includes a spring, the spring being coupled to the guidewire.

4. The eye treatment system of claim 3 , wherein actuation of the actuator causes the spring to move the guidewire between a first position and a second position relative to the handle portion.

5. The eye treatment system of claim 4 , wherein actuation of the actuator causes the spring to move the guidewire in a proximal direction relative to the handle portion.

6. The eye treatment system of claim 1 , wherein the guidewire comprises an s-shape.

7. The eye treatment system of claim 1 , wherein the guidewire comprises a sinusoidal curve shape.

8. The eye treatment system of claim 1 , wherein, when the implant has been delivered into the eye, actuation of the actuator causes the guidewire to withdraw from the ocular implant in a proximal direction.

9. The eye treatment system of claim 1 , wherein the guidewire includes at least one inner lumen.

10. The eye treatment system of claim 9 , wherein the delivery portion further includes a sheath positioned axially over at least a portion of the guidewire and wherein a distal end of the sheath abuts a proximal end of an ocular implant when the ocular implant is positioned on the guidewire, and wherein the distal end of the sheath prevents the ocular implant from moving toward the handle portion as the guidewire withdraws in a proximal direction.

11. The eye treatment system of claim 9 , wherein the guidewire includes at least one opening that provides fluid communication between the inner lumen of the guidewire and an area surrounding the guidewire.

12. The eye treatment system of claim 11 , wherein the area surrounding the guidewire comprises an inner lumen of an ocular implant.

13. The eye treatment system of claim 1 , wherein the delivery system includes at least one fluid delivery feature which delivers fluid from a fluid source and into an inner lumen of the guidewire.

14. The eye treatment system of claim 13 , wherein the fluid from the fluid source includes one or more of a viscoelastic, a drug and a stem cell.

15. The eye treatment system of claim 1 , wherein the ocular implant is formed of a tubular structure having an internal lumen.

16. The eye treatment system of claim 1 , wherein the ocular implant is configured to drain fluid from an anterior chamber of an eye to a supraciliary space of an eye.

17. The eye treatment system of claim 1 , wherein a distal portion of the guidewire is configured to separate a ciliary body of the eye from a sclera of the eye.

18. The eye treatment system of claim 1 , wherein the curved portion of the guidewire has a nominal longitudinal axis and one or more wire peaks separated from the nominal longitudinal axis, wherein each of the peaks contacts an inner surface of the ocular implant to assist in retaining the implant on the guidewire during delivery into the eye.

19. The eye treatment system of claim 1 , further comprising a dampener coupled to the handle portion, the dampener adapted to dampen retraction of the guidewire upon actuation of the actuator.

Assignees

• Novartis Ag

Inventors

• Schaller Michael
• Lari David
• Clauson Luke
• White Nathan
• Lilly Richard S
• Newell Matthew
• Ahmed Iqbal Ike K

Classifications

• A61F2002/9505

  having retaining means other than an outer sleeve, e.g. male-female connector between stent and instrument · CPC title

• A61M5/3257

  Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means · CPC title

• A61M25/09

  Guide wires · CPC title

• A61M25/0905

  extendable, e.g. mechanisms for extension · CPC title

• A61F2/95

  Instruments specially adapted for placement or removal of stents or stent-grafts · CPC title