Filter holder and method for sterilizing the filter holder

Patent metadata

Field	Value
Publication number	US-9903529-B2
Application number	US-201214366509-A
Country	US
Kind code	B2
Filing date	Oct 17, 2012
Priority date	Dec 19, 2011
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

A filter holder for receiving filter cassettes ( 19 ) and a method for sterilizing the filter are provided. The filter holder has first and second parallel plates ( 3, 4 ). The first plate ( 3 ) is fixed and the second plate ( 4 ) is movable along at least one rail ( 2 ) by a drive ( 7, 9 ) so that the filter cassettes ( 19 ) can be clamped between the plates ( 3, 4 ) with a predefined clamping pressure. The drive ( 7, 9 ) is designed to be removable. The at least one rail ( 2 ) has at least one tension rod ( 5 ) with a spring clamping element ( 6 ) so that the first and second plates ( 3, 4 ) can be clamped with a pre-definable pressure against the filter cassettes ( 19 ).

First claim

The invention claimed is:

1. A filter holder ( 1 ), comprising:
at least one rail ( 2 );
first, second and third parallel plates ( 3 , 4 , 8 ), the first and third parallel plates ( 3 , 8 ) being fixed on the at least one rail ( 2 ), and spaced from one another, the second parallel plate ( 4 ) being between the first and third parallel plates ( 3 , 8 ) and being movable relative to the at least one rail ( 2 ) and relative to the first and third parallel plates ( 3 , 8 );
a drive ( 7 ) that is removably attached by a locking device or a threaded connection to a side of the third parallel plate ( 8 ) facing away from the first and second parallel plates ( 3 , 4 ), the drive ( 7 ) being operable for moving the second parallel plate ( 4 ) toward and away from the first parallel plate ( 3 ) and for generating a predefinable clamping pressure; and
at least one tension rod ( 5 ) parallel with the at least one rail ( 2 ) and having a spring tensioning element ( 6 ) attached on a side of the first parallel plate ( 3 ) facing away from the second and third parallel plates ( 4 , 8 ), the at least one tension rod ( 5 ) connecting the first and second parallel plates ( 3 , 4 ) to each other and being configured for generating a predefined tension rod pressure on the first and second parallel plates exerted by the spring tensioning element ( 6 ), whereby filter cassettes ( 19 ) can be clamped between the first and second parallel plates ( 3 , 4 ) at the predefined tension rod pressure when the drive ( 7 ) is removed.

2. The filter holder of claim 1 , further comprising:
a cassette stack ( 18 ) having a plurality of the filter cassettes ( 19 ) in a stacked array and first and second filter plates ( 20 , 21 ) at opposite ends of the stacked array of the filter cassettes ( 19 ), the cassette stack ( 18 ) being disposed to so that the first filter plate ( 20 ) faces the first parallel plate ( 3 ) of the filter holder ( 1 ) and the second filter plate ( 21 ) faces the second parallel plate ( 4 ) of the filter holder ( 1 ), the first filter plate ( 20 ) defining a feed plate or a retentate that is configured for distributing fluid that is to be filtered.

3. The filter holder of claim 1 , wherein
the drive ( 7 ) comprises a pressurizable hydraulic cylinder ( 9 ) that comprises a movable piston ( 11 ) configured to move the second parallel plate ( 4 ) toward the first parallel plate ( 3 ) with the predefined clamping pressure.

4. The filter holder of claim 3 , wherein
the hydraulic cylinder ( 9 ) is connected to a pump ( 15 ) by a hydraulic line ( 14 ) and a pressure gauge ( 16 ) is arranged between the pump ( 15 ) and the hydraulic cylinder ( 9 ).

5. The filter holder of claim 1 , wherein
the at least one rail ( 2 ) comprises four rails ( 2 ) on which the second parallel plate ( 4 ) is movable relative to the first parallel plate ( 3 ).

6. The filter holder of claim 1 , wherein
the at least one tension rod ( 5 ) comprises two tension rods ( 5 ) each having one spring tensioning element ( 6 ), the tension rods ( 5 ) connecting the first and second parallel plates ( 3 , 4 ) to each other and being configured to generate the predefinable tension rod pressure.

7. The filter holder of claim 1 , wherein
the filter holder ( 1 ) is autoclavable when the drive ( 7 ) is removed.

8. An autoclavable filter assembly, comprising:
a cassette stack ( 18 ) having a plurality of the filter cassettes ( 19 ) in a stacked array; and
a filter holder ( 1 ) for holding the cassette stack ( 18 ), the filter holder ( 1 ) including:
at least one rail ( 2 );
first, second and third parallel plates ( 3 , 4 , 8 ), the first and third parallel plates ( 3 , 8 ) being fixed on the at least one rail ( 2 ), the second parallel plate ( 4 ) being between the first and third parallel plates ( 3 , 8 ) and being movable relative to the at least one rail ( 2 ) and relative to the first and third parallel plates ( 3 , 8 ) with the cassette stack ( 19 ) being between the first and second parallel plates ( 3 , 4 );
a drive ( 7 ) that is removably attached by a locking device or a threaded connection to a side of the third parallel plate ( 8 ) facing away from the first and second parallel plates ( 3 , 4 ), the drive ( 7 ) being configured for moving the second parallel plate ( 4 ) toward and away from the first parallel plate ( 3 ) and for generating a predefinable clamping pressure on the cassette stack ( 18 ); and
at least one tension rod ( 5 ) parallel with the at least one rail ( 2 ) and connecting the first and second parallel plates ( 3 , 4 ) to each other, the at least one tension rod ( 5 ) having a spring tensioning element ( 6 ) attached on a side of the first parallel plate ( 3 ) facing away from the second and third parallel plates ( 4 , 8 ) and clamping the first and second parallel plates ( 3 , 4 ) against the cassette stack ( 18 ) independent of the drive ( 7 ) and with a predefined tension rod pressure exerted by the spring tensioning element ( 6 ), whereby the drive ( 7 ) can be removed so that remaining parts of the filter assembly can be autoclaved.

9. The filter assembly of claim 8 , wherein the cassette stack ( 18 ) further comprises first and second filter plates ( 20 , 21 ) at opposite ends of the stacked array of the filter cassettes ( 19 ), the cassette stack ( 18 ) being disposed to so that the first filter plate ( 20 ) faces the first parallel plate ( 3 ) of the filter holder ( 1 ) and the second filter plate ( 21 ) faces the second parallel plate ( 4 ) of the filter holder ( 1 ), the first filter plate ( 20 ) defining a feed plate or a retentate that is configured for distributing a fluid that is to be filtered.

10. The filter assembly of claim 8 , wherein the drive ( 7 ) comprises a pressurizable hydraulic cylinder ( 9 ) that comprises a movable piston ( 11 ) configured to clamp the second parallel plate ( 4 ) against the filter cassettes ( 19 ) with the predefined clamping pressure.

11. The filter assembly of claim 10 , wherein the hydraulic cylinder ( 9 ) is connected to the pump ( 15 ) by a hydraulic line ( 14 ) and a pressure gauge ( 16 ) is arranged between a pump ( 15 ) and the hydraulic cylinder ( 9 ).

12. The filter assembly of claim 8 , wherein the at least one rail ( 2 ) comprises four rails ( 2 ) on which the second parallel plate ( 4 ) is movable relative to the first parallel plate ( 3 ).

13. The filter holder of claim 8 , wherein the at least one tension rod ( 5 ) comprises two tension rods ( 5 ) each having one spring tensioning element ( 6 ), the tension rods ( 5 ) enabling the first and second parallel plates ( 3 , 4 ) to be connected to each other and clamped against the filter cassettes ( 19 ) with the predefinable tension rod pressure.

Assignees

• Sartorius Stedim Biotech Gmbh

Inventors

• Ajam Mohammed Saeed
• Mattern Jonas
• Schaefer Jan

Classifications

• B01D2321/32

  By heating or pyrolysis · CPC title

• B01D65/02

  Membrane cleaning or sterilisation {; Membrane regeneration} · CPC title

• B01D65/025

  Removal of membrane elements before washing · CPC title

• B01D2313/06

  External membrane module supporting or fixing means · CPC title

• A61L2/07

  Steam · CPC title