Sweet flavor modifier

Patent metadata

Field	Value
Publication number	US-9902737-B2
Application number	US-201615059142-A
Country	US
Kind code	B2
Filing date	Mar 2, 2016
Priority date	Apr 2, 2010
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

First claim

We claim:

1. A compound selected from the group consisting of:

or a tautomer, and/or a salt thereof.

2. A compound selected from the group consisting of:

or a tautomer, and/or salt thereof.

3. A compound selected from the group consisting of:

or a tautomer, and/or salt thereof.

4. An ingestible composition comprising a compound of claim 1 , or a tautomer or salt thereof and an ingestibly acceptable excipient.

5. The ingestible composition of claim 4 , further comprising one or more sweeteners.

6. The ingestible composition of claim 5 , wherein the sweetener is selected form the group consisting of sucrose, fructose, glucose, galactose, mannose, lactose, tagatose, maltose, corn syrup, D-tryptophan, glycine, erythritol, lactitol, mannitol, sorbitol, xylitol, maltodextrin, maltitol, isomalt, hydrogenated glucose syrup (HGS), hydrogenated starch hydrolyzate (HSH), stevioside, rebaudioside A, other sweet Stevia-based glycosides, carrelame, other guanidine-based sweeteners, saccharin, acesulfame-K, cyclamate, sucralose, alitame, mogroside, neotame, aspartame, other aspartame derivatives, and combinations thereof.

7. The ingestible composition of claim 4 , which has an increased sweet taste as compared to the ingestible composition not containing a compound of claim 1 , as judged by a majority of a panel of at least eight human taste testers.

8. The ingestible composition of claim 4 , which is in form of a food or beverage product, a pharmaceutical composition, a nutritional product, a dietary supplement, over-the-counter medication, or oral care product.

9. The ingestible composition of claim 8 , wherein the food or beverage product is for human or animal consumption.

10. The ingestible composition of claim 8 , wherein the food or beverage product is selected from the group consisting of the Soup category; the Dried Processed Food category; the Beverage category; the Ready Meal category; the Canned or Preserved Food category; the Frozen Processed Food category; the Chilled Processed Food category; the Snack Food category; the Baked Goods category; the Confectionary category; the Dairy Product category; the Ice Cream category; the Meal Replacement category; the Pasta and Noodle category; the Sauces, Dressings, Condiments category; the Baby Food category; the Spreads category; sweet coatings, frostings, or glazes; and combinations thereof.

11. A method of enhancing the sweet taste of an ingestible composition comprising contacting the ingestible composition thereof with a compound of claim 1 , or a tautomer, and/or salt thereof, to form a modified ingestible composition.

12. A sweet enhancing composition, comprising a compound of claim 1 , or a tautomer, and/or salt thereof, in an amount effective to provide sweetening in combination with a first amount of sweetener, wherein the sweetening is more than the sweetening provided by the first amount of sweetener without the compound.

13. An ingestible composition comprising the sweet enhancing composition of claim 12 .

14. The ingestible composition of claim 13 , which is in form of a food or beverage product, a pharmaceutical composition, a nutritional product, a dietary supplement, over-the-counter medication, or oral care product.

15. A flavoring concentrate formulation comprising:
i) as flavor modifying ingredient, a compound of claim 1 , or a tautomer, and/or salt thereof;
ii) a carrier; and
iii) optionally at least one adjuvant.

16. The flavoring concentrate formulation of claim 15 , wherein the at least one adjuvant comprises one or more flavoring agents.

17. The flavoring concentrate formulation of claim 16 , wherein the at least one adjuvant comprises one or more sweeteners.

18. The flavoring concentrate formulation of claim 17 , wherein the at least one adjuvant comprises one or more ingredients selected from the group consisting of a emulsifier, a stabilizer, an antimicrobial preservative, an antioxidant, vitamins, minerals, fats, starches, protein concentrates and isolates, salts, a freezing point depressant, nucleating agent, and combinations thereof.

19. The flavoring concentrate formulation of claim 18 , which is in a form selected from the group consisting of liquid, solid, semi-solid, foamy material, paste, gel, cream, lotion, and combinations thereof.

20. The flavoring concentrate formulation of claim 19 , wherein the compound of claim 1 is in a concentration that is at least 2 times of the concentration in a ready-to-use composition.

Assignees

• Senomyx Inc

Inventors

• Tachdjian Catherine
• Tang Xiao Qing
• Karanewsky Donald S
• Servant Guy
• Li Xiaodong
• Zhang Feng
• Chen Qing
• Zhang Hong
• Davis Timothy
• Darmohusodo Vincent
• Wong Melissa S
• Selchau Victor

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P27/00

  Drugs for disorders of the senses · CPC title

• A61P3/04

  Anorexiants; Antiobesity agents · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title