Use of nitrooxy organic molecules in feed for reducing methane emission in ruminants, and/or to improve ruminant performance

Patent metadata

Field	Value
Publication number	US-9902685-B2
Application number	US-201514848269-A
Country	US
Kind code	B2
Filing date	Sep 8, 2015
Priority date	Dec 20, 2010
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant and/or for improving ruminant animal performance by using, as active compound at least one organic molecule substituted at any position with at least one nitrooxy group, or a salt thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these compounds in feed and feed additives such as premix, concentrates and total mixed ration (TMR) or in the form of a bolus.

First claim

The invention claimed is:

1. A feed composition or feed additive for a ruminant comprising an amount between about 1 mg to about 10 g/kg of feed of 3-nitrooxy propanol sufficient to reduce production of methane emanating from digestive activities of a ruminant by at least 10% calculated in liters per kilogram of dry matter intake when measured in a metabolic chamber.

2. A feed composition or feed additive for reducing the production of methane emanating from the digestive activities of ruminants, wherein the feed composition comprises an amount between about 1 mg/kg of feed to about 10 g/kg of feed sufficient to reduce production of methane emanating from the digestive activities of a ruminant of at least one active organic molecule or a salt thereof selected from the group consisting of 3-nitrooxypropanol, rac-4-phenylbutane-1,2-diyldinitrate, 2-(hydroxymethyl)-2-(nitrooxymethyl)-1,3-propanediol, N-ethyl-3-nitrooxy-propionic sulfonyl amide, 5-nitrooxy-pentanenitrile, 5-nitrooxy-pentane, 3-nitrooxy-propyl propionate, 1,3-bis-nitrooxypropane, 1,4-bis-nitrooxybutane, 1,5-bis-nitrooxypentane, 3-nitrooxy-propyl benzoate, 3-nitrooxy-propyl hexanoate, 3-nitrooxy-propyl 5-nitrooxy-hexanoate, benzylnitrate, isosorbid-dinitrate, N-[2-(nitrooxy)ethyl]-3-pyridinecarboxamide, and bis-(2-nitrooxyethyl) ether.

3. The feed composition or feed additive according to claim 2 which is a mineral premix, a vitamin premix, or a premix including vitamins and minerals or a bolus.

4. The feed composition or feed additive according to claim 2 , wherein the at least one active organic molecule is 3-nitrooxy propanol.

5. The feed composition or feed additive according to claim 2 , wherein the at least one active organic molecule is a mixture of 3-nitrooxy propanol and 1,3-bis-nitrooxypropane.

Assignees

• Dsm Ip Assets Bv

Inventors

• Duval Stephane
• Kindermann Maik

Classifications

• C07D493/04

  Ortho-condensed systems · CPC title

• C07D307/72

  with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 · CPC title

• C07D213/82

  in position 3 · CPC title

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title

• A61K31/275

  Nitriles; Isonitriles · CPC title