Apparatus for measuring properties of an object with acoustically induced electromagnetic waves

Patent metadata

Field	Value
Publication number	US-9901280-B2
Application number	US-9303606-A
Country	US
Kind code	B2
Filing date	Aug 14, 2006
Priority date	Nov 9, 2005
Publication date	Feb 27, 2018
Grant date	Feb 27, 2018

Abstract

A measuring method and apparatus in which a measurable object ( 23 ) is irradiated with acoustic waves to measure a change in property value of charged particles in the object from electromagnetic waves induced thereby. A part ( 2 ) of the measurable object irradiated with an acoustic focused beam ( 1 ) is in a charge distribution state in which positive charged particles ( 3 ) are greater in number in the part ( 2 ) where electromagnetic waves induced by positive charged particles ( 3 ) are not canceled by those induced by negative charged particles ( 4 ) and where net electromagnetic waves ( 6 ) are induced. Since a change in concentration of positive charged particles ( 3 ) and/or negative charged particles ( 4 ) changes the intensity of electromagnetic waves ( 6 ), it is possible to know such a change in concentration of the charged particles from a change in intensity of electromagnetic waves ( 6 ).

First claim

What is claimed is:

1. An apparatus to measure a property of an object with acoustically induced electromagnetic waves, comprising:
an acoustic generator that emits an acoustic wave pulse towards the object, wherein the acoustic generator generates, upon emission of the acoustic wave pulse, electromagnetic noises, which are produced by the acoustic generator and which last after completing the emission of the acoustic wave pulse;
a retainer table to hold the object at a prescribed distance from the acoustic generator such that a time period for the acoustic wave pulse to travel over the prescribed distance between the acoustic generator and the object is longer than duration of the electromagnetic noises which are in form of electromagnetic waves;
means for receiving electromagnetic waves including induced electromagnetic waves which are induced from the object in response to the acoustic wave pulse, and the electromagnetic noises produced by the acoustic generator, the means for receiving electromagnetic waves first receiving the electromagnetic noises and subsequently receiving the induced electromagnetic waves, and the induced electromagnetic waves that are induced from the object in response to the acoustic wave pulse and the electromagnetic noises being separated in time from each other due to the prescribed distance; and
a control, measure and process unit for driving and controlling the acoustic generator, wherein the control, measure and process unit measures and processes the induced electromagnetic waves that are induced from the object in response to the acoustic wave pulse and that are received by the means for receiving electromagnetic waves, and determines at least one of electric, magnetic, and electromagnetic/mechanical properties from one or a combination of intensity, phase and frequency characteristics of the induced electromagnetic waves that are induced from the object in response to the acoustic wave pulse.

2. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in claim 1 , wherein the acoustic generator comprises a plurality of acoustic generators or a plurality of acoustic generators fixed on a concaved surface whose normal is focused on a point,
whereby acoustic wave pulses generated from the plurality of acoustic generators are controlled of their mutual phase by the control, measure and process unit to be focused on a desired position of the object, and a focusing position of acoustic wave pulse is scanned over a two-dimensional surface or three-dimensional volume of the object or the plurality of acoustic generators are scanned mechanically around the object to scan the focusing position of acoustic waves over a two-dimensional surface or three-dimensional volume of the object.

3. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in any one of claims 1 , 2 , wherein the control, measure and process unit includes a Superconducting Quantum Interference Device (SQUID) for detecting a magnetic field.

4. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in claim 1 , wherein the control, measure and process unit includes means for heterodyne-detecting or means for phase-detecting the electromagnetic waves received by the means for receiving electromagnetic waves with a frequency of the acoustic wave pulse, and means for lock-in detecting an electromagnetic wave signal so detected with a pulse frequency of the acoustic wave pulse.

5. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in claim 1 , wherein the control, measure and process unit comprises means for causing broadband ultrashort pulses to be generated from the acoustic generator and means for measuring a frequency of the electromagnetic waves received by the means for receiving electromagnetic waves.

6. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in claim 5 , wherein the means for measuring a frequency of the electromagnetic waves comprises any one or a combination of a bandpass filter, a rock-in amplifier and a spectrum analyzer.

7. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in any one of claims 1 - 2 and 4 - 6 , wherein the object is a nervous tissue representative of a brain or a muscle tissue of a living body, and
wherein the property, which can be determined by the control, measure and process unit, is a charge distribution formed when the neurons or muscle tissues are activated to identify a site of the neurons or muscle tissues that are activated.

8. The apparatus to measure a property of an object with acoustically induced electromagnetic waves as set forth in claim 7 , wherein the control, measure and process unit includes a Superconducting Quantum Interference Device (SQUID) for detecting a magnetic field.

9. An apparatus to measure a property of an object with acoustically induced electromagnetic waves, comprising:
an acoustic generator that emits an acoustic wave pulse towards the object,
a retainer table to hold the object at a prescribed distance from the acoustic generator such that a time period for the acoustic wave pulse to travel over the prescribed distance between the acoustic generator and the object is longer than a pulse duration of the acoustic wave pulse and that a relaxation of the induced electromagnetic waves that are induced from the object in response to the acoustic wave pulse occurs before echo noises in form of electromagnetic waves are produced by the acoustic generator in response to an echo of the acoustic wave pulse;
means for receiving electromagnetic waves including the induced electromagnetic waves and the echo noises; and
a control, measure and process unit for driving and controlling the acoustic generator, wherein the control, measure and process unit measures and processes the induced electromagnetic waves that are induced from the object in response to the acoustic wave pulse and that are received by the means for receiving electromagnetic waves, and determines time dependency of intensities of the induced electromagnetic waves,
wherein the control, measure and process unit determines a relaxation characteristic of a property value for charged particles of the object from the time dependency of the intensities of the induced electromagnetic waves before the echo noises due to the echo are produced.

Assignees

• Ikushima Kenji
• Komiyama Susumu
• Japan Science & Tech Agency

Inventors

• Ikushima Kenji
• Komiyama Susumu

Classifications

• A61B2562/18

  Shielding or protection of sensors from environmental influences, e.g. protection from mechanical damage · CPC title

• G01R33/0213

  using deviation of charged particles by the magnetic field · CPC title

• A61B8/00

  Diagnosis using ultrasonic, sonic or infrasonic waves · CPC title

• G01R33/1269

  of molecules labeled with magnetic beads (magnetic particles for bio assay G01N33/54326) · CPC title

• A61B5/7228

  Signal modulation applied to the input signal sent to patient or subject; Demodulation to recover the physiological signal · CPC title