Method for producing porous calcium phosphate body

Patent metadata

Field	Value
Publication number	US-9896782-B2
Application number	US-201314409475-A
Country	US
Kind code	B2
Filing date	Jun 19, 2013
Priority date	Jun 20, 2012
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

To provide a method for producing a porous calcium phosphate body having open micro-pores, by the method for producing the porous calcium phosphate body, in which calcium phosphate is subjected to electro-spinning.

First claim

What is claimed is:

1. A method for producing a porous calcium phosphate body, wherein calcium phosphate is dispersed into a dispersion medium to form a dispersion liquid, the dispersion liquid is subjected to electrospinning, and wherein a viscosity of the dispersion liquid is in the range of 100 cP to 8,000 cP, and a surfactant is further incorporated into the dispersion liquid at a concentration of 10% by weight or less based on the calcium phosphate, and the shape of the calcium phosphate have a particle form, and the particle form size is less than 50 nanometers.

2. The method for producing the porous calcium phosphate body according to claim 1 , wherein the calcium phosphate to be subjected to electrospinning is hydroxyapatite or tricalcium phosphate.

3. The method for producing the porous calcium phosphate body according to claim 1 , wherein the porous calcium phosphate body includes a porous hydroxyapatite body or a porous tricalcium phosphate body.

4. The method for producing the porous calcium phosphate body according to claim 1 , using hydroxyapatite in which a full width at half maximum of a peak at a diffraction angle: 2θ=46.7° by X-ray diffractometry is 0.5° or more.

5. The method for producing the porous calcium phosphate body according to claim 1 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

6. The method for producing the porous calcium phosphate body according to claim 5 , further dispersing a fiber-formable polymer into the dispersion liquid.

7. The method for producing the porous calcium phosphate body according to claim 5 , wherein calcination is performed in a temperature range of 500° C. or higher.

8. The method for producing the porous calcium phosphate body according to claim 6 , wherein a ratio of calcium phosphate/fiber-formable polymer (weight ratio) is 0.3 or more.

9. The method for producing the porous calcium phosphate body according to claim 2 , wherein the porous calcium phosphate body includes a porous hydroxyapatite body or a porous tricalcium phosphate body.

10. The method for producing the porous calcium phosphate body according to claim 2 , using hydroxyapatite in which a full width at half maximum of a peak at a diffraction angle: 2θ=46.7° by X-ray diffractometry is 0.5° or more.

11. The method for producing the porous calcium phosphate body according to claim 3 , using hydroxyapatite in which a full width at half maximum of a peak at a diffraction angle: 2θ=46.7° by X-ray diffractometry is 0.5° or more.

12. The method for producing the porous calcium phosphate body according to claim 9 , using hydroxyapatite in which a full width at half maximum of a peak at a diffraction angle: 2θ=46.7° by X-ray diffractometry is 0.5° or more.

13. The method for producing the porous calcium phosphate body according to claim 2 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

14. The method for producing the porous calcium phosphate body according to claim 3 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

15. The method for producing the porous calcium phosphate body according to claim 4 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

16. The method for producing the porous calcium phosphate body according to claim 9 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

17. The method for producing the porous calcium phosphate body according to claim 10 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

18. The method for producing the porous calcium phosphate body according to claim 11 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

19. The method for producing the porous calcium phosphate body according to claim 12 , wherein the dispersion liquid is subjected to electrospinning, and then spun fibers are calcined.

Assignees

• Jnc Corp
• Sofsera Corp

Inventors

• Kogai Yasumichi
• Nomi Daisuke
• Hattori Hisashi
• Kawabe Karl Kazushige
• Umebayashi You
• Kataoka Yukinori
• Miyauchi Minoru

Classifications

• C01B25/321

  Methods for converting an alkaline earth metal ortho-phosphate into another ortho-phosphate (by reaction, e.g. of phosphate rock with phosphoric acid C01B25/322) · CPC title

• C01B25/32

  Phosphates of magnesium, calcium, strontium, or barium · CPC title

• D01D5/0007

  Electro-spinning (non-woven fabrics produced by electro-spinning D04H1/728) · CPC title

• C01B25/327 Primary

  After-treatment · CPC title

• D01D5/003

  the material being a polymer solution or dispersion (D01D5/0053 takes precedence) · CPC title