Deactivation of urushiol and method of treatment and prevention of contact dermatitis

Patent metadata

Field	Value
Publication number	US-9896532-B2
Application number	US-201314398427-A
Country	US
Kind code	B2
Filing date	May 1, 2013
Priority date	May 1, 2012
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, cashew nut, and Asian lacquer.

First claim

I claim:

1. A method for deactivating a catechol in a sample, the method comprising the steps of (i) contacting an oxidant and a catalyst with the sample, wherein the catalyst is a nitroxide, (ii) allowing the oxidant to react with the catechol in the sample thereby creating an orthoquinone; (iii) allowing the orthoquinone to react with the oxidant thereby generating a polymer; the method resulting in deactivating the catechol in the sample.

2. A method for deactivating a catechol in a sample, the method comprising the steps of (i) contacting an oxidant and a catalyst with the sample, wherein the catalyst is a nitroxide precursor, (ii) allowing the oxidant to react with the catechol in the sample thereby creating an orthoquinone; (iii) allowing the orthoquinone to react with the oxidant thereby generating a polymer; the method resulting in deactivating the catechol in the sample.

3. The method of claim 1 , wherein the nitroxide is selected from the group consisting of alkyl nitroxide, Fremy's salt, and acyl nitroxide.

4. The method of claim 1 , wherein the nitroxide is tetramethylpiperidinyloxy (TEMPO).

5. The method of claim 2 , wherein the nitroxide precursor is selected from the group consisting of an amine and a hydroxamic acid.

6. The method of claim 1 , the method further comprising the steps of (iv) providing a free radical initiator, (v) allowing the orthoquinone to react with the free radical initiator, thereby generating a semiquinone radical, (vi) allowing the semiquinone radical to auto-oxidize, or (vii) allowing the semiquinone to polymerize, the method resulting in deactivating the orthoquinone.

Assignees

• Univ California

Inventors

• Braslau Rebecca

Classifications

• A61K38/44

  Oxidoreductases (1) · CPC title

• A61K49/0006

  Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity · CPC title

• A61K33/00 Primary

  Medicinal preparations containing inorganic active ingredients · CPC title

• C08G2/16 Primary

  Polymerisation of single ketones · CPC title

• C07C46/06

  of at least one hydroxy group on a six-membered aromatic ring · CPC title