Flavoured nicotine powder inhaler
US-2017035108-A1 · Feb 9, 2017 · US
Nicotine salts, co-crystals, and salt co-crystal complexes
US9896429B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9896429-B2 |
| Application number | US-201514951939-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 25, 2015 |
| Priority date | May 27, 2014 |
| Publication date | Feb 20, 2018 |
| Grant date | Feb 20, 2018 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and/or salt co-crystals are also provided.
First claim
Opening claim text (preview).
What is claimed: 1. A bis-orotic acid salt-co-crystal of nicotine and orotic acid, characterized by an X-ray powder diffraction pattern having peaks at one or more of the following 2-theta diffraction angles: 8.8, 13.4, 17.7, 26.5, and 29.3. 2. The salt-co-crystal of claim 1 , wherein at least about 50% of the salt-co-crystal is in crystalline form. 3. A pharmaceutical product comprising the salt-co-crystal of nicotine and orotic acid of claim 1 and one or more pharmaceutically acceptable excipients. 4. The pharmaceutical product of claim 3 , in a form selected from the group consisting of a pill, tablet, lozenge, capsule, caplet, pouch, gum, inhaler, solution, and cream. 5. A method of preparing the salt-co-crystal of claim 1 , comprising combining nicotine and orotic acid to form a solid and isolating the solid. 6. The method of claim 5 , wherein the combining comprises mixing the nicotine and orotic acid in THF, ethanol, or a mixture thereof. 7. The pharmaceutical product of claim 3 , wherein the one or more pharmaceutically acceptable excipients comprise isomalt.
Assignees
Inventors
Classifications
Two oxygen atoms · CPC title
- C07D401/04Primary
directly linked by a ring-member-to-ring-member bond · CPC title
Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff (reconstituted tobacco products A24B3/14) · CPC title
Fumaric acid · CPC title
electrical · CPC title
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Frequently asked questions
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- What does patent US9896429B2 cover?
- The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with orotic acid are described. The invention further provides methods of preparation and characterization of such nicotine salts. In addition, tobacco products, including smoking articles, smokeless tobacco products, and …
- Who is the assignee on this patent?
- Reynolds Tobacco Co R
- What technology area does this patent fall under?
- Primary CPC classification C07D401/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).