Analysis package for detecting particles in a sample liquid

Patent metadata

Field	Value
Publication number	US-9895691-B2
Application number	US-201514848307-A
Country	US
Kind code	B2
Filing date	Sep 8, 2015
Priority date	Feb 9, 2015
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

According to one embodiment, an analysis package, including a board, an analysis chip provided on the board, the chip including a detector for detecting a particle, a flow channel of a sample liquid, and a liquid receiver of the sample liquid, a first mold layer provided on the analysis chip, the first mold layer including an opening above the liquid receiver, and a second mold layer provided on the board and the first mold layer, the second mold layer including an opening above the opening of the first mold layer, wherein the respective openings of the first and second mold layers are connected above the liquid receiver to allow the sample liquid to be introduced into the liquid receiver from outside.

First claim

What is claimed is:

1. An analysis package comprising:
a board comprising a wiring layer;
an analysis chip provided on the board, the chip comprising a detector for detecting a particle, a flow channel for injecting and ejecting a sample liquid for particle detection to the detector, and a liquid receiver for introducing the sample liquid into the flow channel;
a first mold layer provided on the analysis chip to cover the analysis chip, the first mold layer comprising an opening above the liquid receiver; and
a second mold layer provided on the board and the first mold layer to cover the board and the first mold layer, the second mold layer comprising an opening above the opening of the first mold layer,
wherein the first mold layer and the second mold layer are made of different resins, and
wherein the respective openings of the first and second mold layers are connected above the liquid receiver to allow the sample liquid to be introduced into the liquid receiver from outside.

2. The package of claim 1 , wherein the opening of the second mold layer is greater in diameter than the opening of the first mold layer.

3. The package of claim 1 , wherein the detector is provided at a part of the flow channel, and comprises a microaperture which allows a particle to be detected to pass therethrough and an electrode which allows a voltage to be applied to the sample liquid on an upstream and a downstream side of the microaperture.

4. The package of claim 3 , wherein the flow channel comprises an introduction opening on one end side, the introduction opening allowing the sample liquid to be introduced, and the microaperture is provided on the other end side.

5. The package of claim 3 , wherein the flow channel comprises first and second flow channels, parts of which contact each other, and the microaperture is provided at a contact portion between the first and second flow channels.

6. The package of claim 3 , wherein the flow channel comprises first and second flow channels which overlap or intersect with each other, and the microaperture is provided at an overlap or an intersection of the first and second flow channels.

7. The package of claim 1 , further comprising a semiconductor device for detection and an electrical signal input/output terminal provided on the board, to convert a detection result of the detector into an electrical signal,
wherein the second mold layer is provided on the semiconductor device to cover the semiconductor device.

8. The package of claim 1 , further comprising:
a first shield metal provided on a back surface of the board; and
a second shield metal provided on an opposite side to the first mold layer of the second mold layer.

9. The package of claim 8 , further comprising a housing accommodating the board, the analysis chip, and the respective mold layers,
wherein the second shield metal is provided on a top surface of the housing.

10. The package of claim 1 , further comprising pillars provided in the flow channel.

11. The package of claim 1 , further comprising a housing to cover the board and the second mold layer.

12. The package of claim 1 , wherein:
the second mold layer is provided above and beside the analysis chip,
an upper surface of the analysis chip is covered by the second mold layer with the first mold layer being in between the upper surface of the analysis chip and the second mold layer, and
a side surface of the analysis chip is covered by the second mold layer with the first mold layer not being provided in between the side surface of the analysis chip and the second mold layer.

13. The package of claim 1 , wherein:
the first mold layer is provided on an upper surface of the board, and
the second mold layer is provided on an upper surface of the first mold layer and on a side surface of the board and a lower surface of the board.

14. The package of claim 13 , wherein the second mold layer is integrally provided on the upper surface of the first mold layer, the side surface of the board, and the lower surface of the board.

15. An analysis package comprising:
a board comprising a wiring layer;
an analysis chip provided on the board, the chip comprising first and second flow channels which overlap or intersect with each other, a microaperture for particle detection provided at an overlap or an intersection of the first and second flow channels, a liquid receiver for introducing a sample liquid into the flow channels, and an electrode which allows a voltage to be applied to the sample liquid on an upstream side and a downstream side of the microaperture;
a first mold layer provided on the analysis chip to cover the analysis chip, the first mold layer comprising an opening above the liquid receiver; and
a second mold layer provided on the board and the first mold layer to cover the board and the first mold layer, the second mold layer comprising an opening above the opening of the first mold layer,
wherein the first mold layer and the second mold layer are made of different resins, and
wherein the respective openings of the first and second mold layers are connected above the liquid receiver to allow the sample liquid to be introduced into the liquid receiver from outside.

16. The package of claim 15 , wherein the opening of the second mold layer is greater in diameter than the opening of the first mold layer.

17. The package of claim 15 , further comprising a semiconductor device for detection and an electrical signal input/output terminal provided on the board to convert a detection result of the detector into an electrical signal,
wherein the second mold layer is provided on the semiconductor device to cover the semiconductor device.

18. The package of claim 15 , further comprising:
a first shield metal provided on a back surface of the board; and
a second shield metal provided on an opposite side to the first mold layer of the second mold layer.

19. The package of claim 18 , further comprising a housing accommodating the board, the analysis chip, and the respective mold layers,
wherein the second shield metal is provided on a top surface of the housing.

20. The package of claim 15 , wherein:
the second mold layer is provided above and beside the analysis chip,
an upper surface of the analysis chip is covered by the second mold layer with the first mold layer being in between the upper surface of the analysis chip and the second mold layer, and
a side surface of the analysis chip is covered by the second mold layer with the first mold layer not being provided in between the side surface of the analysis chip and the second mold layer.

21. The package of claim 15 , wherein:
the first mold layer is provided on an upper surface of the board, and
the second mold layer is provided on an upper surface of the first mold layer and on a side surface of the board and a lower surface of the board.

22. The package of claim 21 , wherein the second mold layer is integrally provided on the upper surface of the first mold layer, the side surface of the board, and the lower surface of the board.

23. An analysis package comprising:
a board comprising a wiring layer;
an analysis chip provided on the board, the chip comprising first and second flow channels which overlap or intersect with each other, a microaperture for particle detection provided at an overlap or an intersection of the first and second flow channels, a liquid receiver for introducing a sample liquid into the flow channels,

Assignees

• Toshiba Kk

Inventors

• Hamasaki Hiroshi
• Nishigaki Michihiko
• Onozuka Yutaka
• Kobayashi Kentaro
• Miki Hiroko
• Nakamura Naofumi

Classifications

• G01N33/48721

  Investigating individual macromolecules, e.g. by translocation through nanopores (Coulter counters in general G01N15/12; fabrication methods for nanoscale apertures B81B1/00; sequencing of nucleic acids C12Q1/68) · CPC title

• G01N27/3273

  Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title

• G01N15/12

  by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle · CPC title

• B01L3/5027 Primary

  by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip · CPC title

• B01L2400/086

  using baffles or other fixed flow obstructions · CPC title