Cellular Adjuvants for Viral Infection
US-2024299521-A1 · Sep 12, 2024 · US
Aluminum compounds for use in therapeutics and vaccines
US9895437B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9895437-B2 |
| Application number | US-201213449596-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 18, 2012 |
| Priority date | Apr 18, 2012 |
| Publication date | Feb 20, 2018 |
| Grant date | Feb 20, 2018 |
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Abstract
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The invention relates to means and methods for preparing aqueous composition comprising aluminum and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminum content. The invention further relates to aqueous compositions comprising a protein and an aluminum-salt, said composition comprising less than 350 ppb heavy metal based on the weight of the aqueous composition.
First claim
Opening claim text (preview).
What is claimed is: 1. An aqueous composition comprising a Japanese Encephalitis Virus (JEV) protein and an aluminum salt, wherein the aluminum salt is selected to provide an aqueous composition comprising less than 3 ppb Cu based on the weight of the aqueous composition. 2. The aqueous composition according to claim 1 , which has been stored at temperatures higher than 20° C. for at least 1 month. 3. The aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal, wherein said heavy metal is selected from Ni, W, Co, Os, Ru, Cd, Ag, Fe, V, Cr, Pb, Rb and Mo. 4. The aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal, wherein said heavy metal is selected from Ni, W, Co, Os, Ru, Cd, Ag, Fe and V. 5. The aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal, wherein said heavy metal is Ni. 6. The aqueous composition according to claim 1 , comprising less than 350 ppb heavy metal, wherein said heavy metal is present in ionic form. 7. The aqueous composition according to claim 1 , wherein the aluminum salt is aluminum hydroxide (Al(OH)3) or aluminum phosphate (AlPO4). 8. The aqueous composition according to claim 1 , wherein the aluminum salt is aluminum hydroxide (Al(OH)3). 9. The aqueous composition according to claim 1 , further comprising a reactive compound selected from the group consisting of a redox active compound, a radical building compound, a stabilizing compound and a combination of any thereof. 10. The aqueous composition according to claim 1 , further comprising a reactive compound selected from the group consisting of formaldehyde, ethanol, chloroform, trichloroethylene, acetone, polyethylene glycol tert-octylphenyl ether, deoxycholate, diethylpyrocarbonate, sulphite, Na2S2O5, beta-proprio-lacton, polysorbate optionally Polysorbate 20 or Polysorbate 80, O2, phenol, poloxamer type copolymers, and a combination of any thereof. 11. The aqueous composition according to claim 1 , comprising between 5 μg/ml and 50 mg/ml aluminum. 12. The aqueous composition according to claim 1 , comprising between 50 m/ml and 5 mg/ml aluminum. 13. The aqueous composition according to claim 1 , comprising between 5 ppb and 250 ppb Fe based on the weight of the aqueous composition. 14. The aqueous composition according to claim 1 , comprising less than 40 ppb Ni based on the weight of the aqueous composition. 15. The aqueous composition according to claim 1 , wherein said protein is protein within formaldehyde inactivated virus particles. 16. The aqueous composition according to claim 1 , further comprising sulphite. 17. A JEV vaccine comprising the aqueous composition according to claim 1 . 18. The aqueous composition according to claim 1 , wherein said composition comprises less than 2.5 ppb Cu based on the weight of the aqueous composition.
Assignees
Inventors
Classifications
Immunostimulants · CPC title
Antibacterial agents · CPC title
Antivirals · CPC title
- A61K39/39Primary
characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title
from virus · CPC title
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Frequently asked questions
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- What does patent US9895437B2 cover?
- The invention relates to means and methods for preparing aqueous composition comprising aluminum and a protein said composition comprising less than 700 ppm heavy metal on the basis of weight with respect to the aluminum content. The invention further relates to aqueous compositions comprising a protein and an aluminum-salt, said composition comprising less than 350 ppb heavy metal based on the…
- Who is the assignee on this patent?
- Schlegl Robert, Moehlen Michael, Wruss Juergen, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification A61K39/39. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 20 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).