Lactobacillus plantarum isolated from leaves of Camellia sinensis

Patent metadata

Field	Value
Publication number	US-9895401-B2
Application number	US-201615097847-A
Country	US
Kind code	B2
Filing date	Apr 13, 2016
Priority date	Jun 10, 2011
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

Disclosed are novel Lactobacillus plantarum strains as well as a composition containing the novel Lactobacillus plantarum strains or a culture thereof.

First claim

The invention claimed is:

1. A method of treating diarrhea, said method comprising administering an effective dose of Lactobacillus plantarum APsulloc 331263 (Accession No. KCCM11180P) strain, an extract thereof, or a culture solution thereof to a subject in need of treating diarrhea, wherein the strain has acid resistance at pH 2 to pH 4, and wherein the strain has bile resistance at 0.3-0.5% bile concentration,
wherein the strain does not ferment rhamnose, inulin, or xylitol,
wherein the strain produces D-type lactic acid in an amount of 70% or less based on a sum of amounts of the D-type lactic acid and L-type lactic acid produced.

2. The method according to claim 1 , wherein the strain, the extract thereof, or the culture solution thereof is administered in a composition, wherein the composition further comprises at least one of a surfactant, excipient, wetting agent, emulsifier, suspending agent, salt or buffer for osmotic pressure control, colorant, flavoring agent, stabilizer, preservative, and preserved agent.

3. The method according to claim 1 , wherein the strain is isolated from tea tree ( Camellia sinensis ) leaves.

4. The method according to claim 1 , wherein the strain has acid resistance at pH 2 to pH 4 for 0.5 hour to 5 hours.

5. The method of claim 1 , wherein the effective dose is 0.1 mg/kg/day to 5000 mg/kg/day.

6. The method of claim 1 , wherein administration is oral or parenteral.

Assignees

• Amorepacific Corp

Inventors

• Kwack Il Young
• You Se Jin
• Park Tae Hun
• Lee Bum Jin
• Shin Kye Ho
• Chung Jin Oh
• Cho Jun Cheol

Classifications

• A61K35/747 Primary

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title

• A61P1/10

  Laxatives · CPC title

• A61K36/82

  Theaceae (Tea family), e.g. camellia · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A23L29/065

  Microorganisms (addition of bacteria for nutritional purposes A23L33/135) · CPC title