Glycoside derivatives and uses thereof

Patent metadata

Field	Value
Publication number	US-9895389-B2
Application number	US-201615134016-A
Country	US
Kind code	B2
Filing date	Apr 20, 2016
Priority date	Oct 20, 2009
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

This invention relates to compounds represented by formula (I):

wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

First claim

We claim:

1. A method of treating obesity, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound:

or a pharmaceutically acceptable salt thereof.

2. A method of treating obesity, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound:

or a pharmaceutically acceptable salt thereof.

3. A method of treating obesity, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound:

or a pharmaceutically acceptable salt thereof.

4. A method of treating obesity, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound:

or a pharmaceutically acceptable salt thereof.

Assignees

• Novartis Ag

Inventors

• Bebernitz Gregory Raymond
• Bock Mark G
• Reddy Dumbala Srinivas
• Hajare Atul Kashinath
• Vyavahare Vinod
• Bhosale Sandeep Bhausaheb
• Kurhade Suresh Eknath
• Salunkhe Videsh
• Shaikh Nadim S
• Bhuniya Debnath
• Palle P Venkata
• Feng Lili
• Liang Jessica

Classifications

• A61P9/12

  Antihypertensives · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P3/06

  Antihyperlipidemics · CPC title

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P3/08

  for glucose homeostasis (pancreatic hormones A61P5/48) · CPC title