Cannabinoids for use in the treatment of neuropathic pain

Patent metadata

Field	Value
Publication number	US-9895342-B2
Application number	US-201214118563-A
Country	US
Kind code	B2
Filing date	May 18, 2012
Priority date	May 20, 2011
Publication date	Feb 20, 2018
Grant date	Feb 20, 2018

Abstract

The present invention relates to cannabinoids for use in the treatment of neuropathic pain. Preferably the cannabinoids are one or more phytocannabinoids of: cannabigerol (CBG), cannabichromene (CBC), cannabidivarin (CBDV) or tetrahydrocannabivarin (THCV). More preferably the phytocannabinoids are isolated and/or purified from cannabis plant extracts.

First claim

The invention claimed is:

1. A method of treating a patient with neuropathic pain consisting essentially of administering to the patient an effective amount of cannabidivarin (CBDV) wherein the CBDV is of a purity of greater than 99% (w/w), or is produced synthetically and does not include cannabidiol (CBD) and/or tetrahydrocannabinol (THC).

2. The method as claimed in claim 1 , wherein the neuropathic pain is peripheral neuropathic pain.

3. The method as claimed in claim 2 , wherein the peripheral neuropathic pain is allodynia.

4. The method as claimed in claim 1 , wherein the CBDV is present in an effective human daily dose to relieve neuropathic pain.

5. The method as claimed in claim 4 , wherein the effective human daily dose of CBDV is between 5 mg and 100 mg.

6. The method as claimed in claim 5 , wherein the effective human daily dose of CBDV is between 10 mg and 50 mg.

7. The method as claimed in claim 1 , wherein the CBDV is packaged for use for an extended treatment period.

8. The method as claimed in claim 7 , wherein the extended treatment period is at least 7 days.

9. The method as claimed in claim 1 , wherein the CBDV is administered to the patient in combination with one or more other medicinal substances used in the treatment of neuropathic pain.

Assignees

• Maione Sabatino
• Rossi Francesco
• Guy Geoffrey
• Stott Colin
• Kikuchi Tetsuro
• Gw Pharma Ltd

Inventors

• Maione Sabatino
• Rossi Francesco
• Guy Geoffrey
• Stott Colin
• Kikuchi Tetsuro

Classifications

• A61P25/04

  Centrally acting analgesics, e.g. opioids · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61P29/02

  without antiinflammatory effect · CPC title

• A61K31/658 Primary

  o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol · CPC title

• A61K31/352 Primary

  condensed with carbocyclic rings, e.g. methantheline  {(cannabinoids A61K31/658)} · CPC title