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Method for producing induced pluripotent stem cells
US9890360B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9890360-B2 |
| Application number | US-201414914986-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 28, 2014 |
| Priority date | Aug 28, 2013 |
| Publication date | Feb 13, 2018 |
| Grant date | Feb 13, 2018 |
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Abstract
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A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
First claim
Opening claim text (preview).
The invention claimed is: 1. An in vitro method for producing a candidate colony of induced pluripotent stem cells, comprising: bringing a nuclear reprogramming substance including at least a Distal-less homeobox 4 (DLX4) gene or a translation product thereof, an OCT3/4 gene or a translation product thereof, and a SOX2 gene or a translation product thereof into contact with a dental pulp cell to produce the candidate colony. 2. The method according to claim 1 , wherein the nuclear reprogramming substance further includes a gene in a KLF4 family or a translation product thereof. 3. The method according to claim 2 , wherein the gene in the KLF4 family or the translation product thereof is a KLF4 gene or a translation product thereof. 4. The method according to claim 1 , wherein the pulp cell is a pulp cell before a stage of completion of tooth root formation. 5. The method according to claim 1 , further comprising: screening the candidate colony using morphological evaluation. 6. An in vitro method for producing a candidate colony of induced pluripotent stem cells, comprising: bringing a nuclear reprogramming substance including at least a DLX4 gene or a translation product thereof, an OCT3/4 gene or a translation product thereof, a SOX2 gene or a translation product thereof, and a KLF4 gene or a translation product thereof into contact with a skin-derived fibroblast to produce the candidate colony. 7. The method according to claim 6 , further comprising: screening the candidate colony using morphological evaluation.
Assignees
Inventors
Classifications
Klf-4 · CPC title
Transcription factors · CPC title
- C12N5/0696Primary
Artificially induced pluripotent stem cells, e.g. iPS · CPC title
Sox-2 · CPC title
Genetically modified cells · CPC title
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- What does patent US9890360B2 cover?
- A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
- Who is the assignee on this patent?
- Univ Gifu, Aist
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0696. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 13 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).