Prostamides for the treatment of glaucoma and related diseases

Patent metadata

Field	Value
Publication number	US-9890118-B2
Application number	US-201615202333-A
Country	US
Kind code	B2
Filing date	Jul 5, 2016
Priority date	Oct 6, 2004
Publication date	Feb 13, 2018
Grant date	Feb 13, 2018

Abstract

Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.

First claim

What is claimed is:

1. A compound having the formula:

or a salt thereof,
wherein:
the hatched wedge indicates an α configuration and the solid wedge indicates a β configuration;
the dashed lines indicate the presence or absence of a double bond;
A and B are both CHOH, or A is CHOH and B is C═O, or B is CHOH and A is C═O;
R 3 is n-butyl or W—Ar;
Ar is

W is CH 2 ;
R 4 is hydrogen or C 1 to C 4 alkyl; and

2. The compound of claim 1 wherein the compound is:

3. A compound having the formula:

Assignees

• Allergan Inc

Inventors

• Woodward David F
• Burk Robert M

Classifications

• C07D233/24

  Radicals substituted by nitrogen atoms not forming part of a nitro radical · CPC title

• A61K31/137

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• C07D209/14

  Radicals substituted by nitrogen atoms, not forming part of a nitro radical · CPC title

• C07C2601/08

  the ring being saturated · CPC title

• C07C405/0041 Primary

  containing nitrogen · CPC title