Ultrasonically cleaned low-pressure filter

Patent metadata

Field	Value
Publication number	US-9889394-B2
Application number	US-201414266389-A
Country	US
Kind code	B2
Filing date	Apr 30, 2014
Priority date	May 3, 2013
Publication date	Feb 13, 2018
Grant date	Feb 13, 2018

Abstract

A filter device having a sonotrode connected to a filtration assembly. The filtration assembly has a filter body having a fluid passage. The filter body has a filter across the fluid passage. The filter assembly has a resonant frequency and the sonotrode is adapted to vibrate the filter assembly at or near the resonant frequency.

First claim

What is claimed is:

1. A method comprising:
flowing a sample through a filter device to filter the sample, wherein particulates are captured by a filter material of a filter assembly, wherein the filter device comprises a sonotrode having a plurality of piezoelectric discs attached to the filter assembly;
vibrating the filter device at or near a resonate frequency of the filter device to remove the particulates from the filter material, wherein the sonotrode is operated at voltages of 5-50 Vrms and at an impedance of 20 Ohms to 500 Ohms to vibrate the filter assembly; and
vibrating the filter device with the sonotrode in excess of 40,000 cycles without replacing the filter material,
wherein vibrating the filter device comprises monitoring the resonant or near-resonant frequency and altering power input to the filter device with a controller to monitor the number of sonotrode cycles and to maintain a phase difference between voltage applied to the sonotrode and current applied to the sonotrode of less than 30 degrees.

2. The method of claim 1 , wherein the sonotrode uses less than 5 W of power.

3. The method of claim 1 , wherein the removed particles are back flushed to waste.

4. The method of claim 1 , wherein a filter of the filter device extends transversely across a fluid path, wherein the filter material has a porosity with pores having a size in the range of 0.1-5.0 and wherein the filter device is vibrated longitudinally along a longitudinal axis of the filter device.

5. The method of claim 1 , wherein the sample comprises a blood sample.

6. The method of claim 1 , wherein the sample is flowed from a low-pressure system into the filter device.

7. The method of claim 6 , wherein the filtered sample is flowed to an analytical section.

8. A system for analyzing a sample, comprising:
a low pressure section adapted to fluidly move a sample;
an analytical section adapted to analyze the sample;
a high-pressure section adapted to move the sample from the analytical section to a containment portion;
wherein the low-pressure section includes a filter device comprising:
a body comprising a sonotrode, the sonotrode having a plurality of piezoelectric discs and is operated at voltages of 5-50 Vrms;
a filtration assembly connected to the body, the filtration assembly comprising a filter body having a fluid passage, the filter body having a filter across the fluid passage,
wherein the filter has a porosity with pores having a size in the range of 0.1-5.0 μm, wherein the filter assembly has a resonant frequency and wherein the sonotrode is adapted to vibrate the filter assembly at or near the resonant frequency at an impedance of 20 Ohms to 500 Ohms, and further wherein the sonotrode is configured to vibrate in excess of 40,000 cycles without having to replace the filter; and

a controller coupled to the filter assembly, the controller adapted to monitor the number of sonotrode cycles and to monitor and alter power input to the filter device to maintain resonance or near-resonance.

9. The system of claim 8 , wherein the filter body comprises a first filter body portion and a second filter body portion.

10. The system of claim 9 , wherein the filter is located between the first filter body portion and the second filter body portion.

11. The system of claim 8 , wherein the filter body defines a filter chamber within the fluid passage, the filter being positioned within the filter chamber.

12. The system of claim 11 , wherein a portion of filter chamber defines a support feature that supports filter material of the filter.

13. The system of claim 8 , wherein the resonant frequency is an ultrasonic frequency.

14. The system of claim 13 , wherein the sonotrode is adapted to vibrate the filter device at the resonant frequency using less than 5 W of power.

15. The system of claim 8 , wherein the filter is transverse to an axis within the sonotrode.

16. The system of claim 15 , wherein the sonotrode is adapted to vibrate the filter device longitudinally along the axis.

Assignees

• Bio Rad Laboratories

Inventors

• Day Richard
• Burcher Michael
• Wrench Nathan
• Myszko Marek
• Hayes Matthew

Classifications

• G01N2001/4088

  filtration · CPC title

• G01N1/34 Primary

  Purifying; Cleaning {(processes or apparatus for extracting or separating nucleic acids from biological samples C12N15/1003)} · CPC title

• B01D29/72

  involving vibrations · CPC title

• B01D29/62 Primary

  Regenerating the filter material in the filter (devices for taking out of action one or more units of multi-unit filters, e.g. for regeneration, B01D35/12) · CPC title