Biodegradable stent with adjustable degradation rate

Patent metadata

Field	Value
Publication number	US-9889238-B2
Application number	US-50697309-A
Country	US
Kind code	B2
Filing date	Jul 21, 2009
Priority date	Jul 21, 2009
Publication date	Feb 13, 2018
Grant date	Feb 13, 2018

Abstract

A biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal.

First claim

What is claimed is:

1. A stent for treating a diseased section of a blood vessel, comprising:
a polymeric scaffolding comprising poly(L-lactide) and particles of L-lactide monomer mixed or dispersed within the poly(L-lactide), wherein the size of the particles is between 100 nm and 1000 nm,
wherein the crystallinity of the poly(L-lactide) is between 20-50%,
wherein the L-lactide monomer is between 0.05 and 0.5 wt % of the scaffolding,
and wherein the number average molecular weight of the poly(L-lactide) is between 60,000 and 300,000, relative to polystyrene standards.

2. The stent of claim 1 , wherein the scaffolding comprises greater than 95 wt % poly(L-lactide).

3. The stent of claim 1 , wherein the scaffolding is composed of a pattern of struts, the pattern including a plurality of cylindrical rings connected by linking struts.

4. The stent of claim 3 , wherein the struts have a rectangular cross-section, the cross-sectional area being between 20,000 and 25,000 μm 2 .

5. The stent of claim 1 , wherein the scaffolding has polymer chain orientation induced by radial expanding a tube between 200-500% and forming the stent therefrom.

Assignees

• Wang Yunbing
• Oberhauser James
• Ma Xiao
• Abbott Cardiovascular Systems Inc

Inventors

• Wang Yunbing
• Oberhauser James
• Ma Xiao

Classifications

• A61F2/82

  Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07) · CPC title

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• B23K2103/42

  Plastics other than composite materials · CPC title

• B23K26/402

  involving non-metallic material, e.g. isolators · CPC title

• A61L31/148 Primary

  Materials at least partially resorbable by the body · CPC title