Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution
US-9040033-B2 · May 26, 2015 · US
US9884922B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9884922-B2 |
| Application number | US-201715449725-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 3, 2017 |
| Priority date | Mar 11, 2016 |
| Publication date | Feb 6, 2018 |
| Grant date | Feb 6, 2018 |
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Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS.
Opening claim text (preview).
That which is claimed is: 1. Hypromellose acetate succinate having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the hypromellose acetate succinate has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the hypromellose acetate succinate has been directly replaced. 2. The hypromellose acetate succinate according to claim 1 , wherein a 10% by weight solution of the hypromellose acetate succinate in an aqueous alkali solution has a transmittance of 70% or more. 3. The hypromellose acetate succinate according to claim 2 , wherein the aqueous alkali solution is aqueous ammonia. 4. A composition comprising the hypromellose acetate succinate according to claim 1 and a solvent. 5. The composition according to claim 4 , wherein the composition is adapted for use as a coating composition. 6. The composition according to claim 4 , wherein the solvent is aqueous ammonia.
with hydroxylated hydrocarbon radicals; Esters, ethers, or acetals thereof · CPC title
Diluents or solvents · CPC title
Preparation of cellulose ether-esters · CPC title
Cellulose acetate · CPC title
Cellulose acetate · CPC title
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