Small molecule inhibitors of mcl-1 and uses thereof
US-2015045357-A1 · Feb 12, 2015 · US
Small molecule inhibitors of Mcl-1 and uses thereof
US9884841B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9884841-B2 |
| Application number | US-201615134098-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2016 |
| Priority date | Apr 20, 2015 |
| Publication date | Feb 6, 2018 |
| Grant date | Feb 6, 2018 |
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- Title
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- Abstract
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Abstract
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This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
First claim
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What is claimed is: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt, solvate, thereof. 2. A composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
Assignees
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Classifications
only substituted in position 4, e.g. isoniazid, iproniazid · CPC title
Sulfonamides (compounds containing a para-N-benzene-sulfonyl-N- group A61K31/63) · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine · CPC title
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring · CPC title
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Frequently asked questions
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- What does patent US9884841B2 cover?
- This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.
- Who is the assignee on this patent?
- Univ Michigan Regents
- What technology area does this patent fall under?
- Primary CPC classification C07D333/34. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 06 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).