Nano-aerosol generation system and methods

Patent metadata

Field	Value
Publication number	US-9878122-B2
Application number	US-201113881651-A
Country	US
Kind code	B2
Filing date	Oct 25, 2011
Priority date	Oct 25, 2010
Publication date	Jan 30, 2018
Grant date	Jan 30, 2018

Abstract

The invention provides methods and apparatus for stable generation and delivery of solid nano-particles in aerosols that simultaneously maintain high nano-particle concentration, and which avoid coagulation and agglomeration of the nano-particles. The apparatus includes a Collison nebulizer is in communication with a plenum. The Collison nebulizer includes a port for introducing a helium gas flow into the Collison nebulizer. The plenum includes component(s) for providing flow of uniform axially symmetrical dry air around the nano-particles entrained in the helium gas flow in the plenum. Preferably, the plenum includes an uniformity screen and a reduction in the plenum circumference downstream from the uniformity screen. In some preferred aspects, the invention provides methods of introducing nanoparticles into the lungs of test animals. The present invention allows more than 0.5 mass % of the nano-particles to be deposited in an animal's lungs.

First claim

We claim:

1. A method for producing a flow of an aerosol comprising nano-particles comprising the steps of:
providing a Collison nebulizer in communication with a plenum,
introducing nano-particles into the Collison nebulizer as a colloidal suspension in water,
providing a helium gas flow into the Collison nebulizer, thereby entraining the nano-particles into the helium gas flow,
directing the nano-particles entrained in the helium gas flow out an exit of the Collison nebulizer and into the plenum, and
providing a flow of dry air through an inlet around the nano-particles entrained in the helium gas flow in the plenum.

2. The method of claim 1 wherein the nano-particles are synthesized in water.

3. The method of claim 1 wherein the plenum is provided as having a reduction in the circumference of the plenum downstream from the inlet, wherein the reduction in the circumference of the plenum is in the direction of flow from the inlet through the plenum, and further including the step of generating a venturi effect at the reduction in the circumference of the plenum, thereby accelerating and mixing the nano-particles entrained in the helium gas flow.

4. The method of claim 1 wherein the plenum is provided as having uniformity screen and flowing the dry air through the uniformity screen.

5. The method of claim 4 wherein the plenum is provided as having a reduction in the circumference downstream from the uniformity screen, and further including the step of generating a venturi effect at the reduction in the circumference of the plenum, thereby accelerating and mixing the nano-particles entrained in the helium gas flow.

6. The method of claim 1 wherein the step of providing the helium gas flow into the Collison nebulizer is conducted at a helium pressure of 94 psi (6.5 bar) or more.

7. The method of claim 1 wherein the nano-particles comprise SiO 2 .

8. The method of claim 1 wherein the nano-particles comprise metal oxides.

9. The method of claim 8 wherein the metal oxide nano-particles comprise functional groups attached to the surface of the nano-particles.

10. The method of claim 1 wherein the nano-particles entrained in the helium gas an average particle size of 100 nm or less.

11. The method of claim 1 wherein the dry air comprises a uniform axially symmetrical flow around the nano-particles entrained in the helium gas flow in the plenum.

12. A method delivering an aerosol comprising nano particles to an animal's lungs through the animal's nose comprising the steps of claim 1 , and further comprising:
passing the nano-particles entrained in a helium-air mixture through the plenum to a nose port, and
allowing an animal to breath the nano-particles through the nose port.

13. The method of claim 12 comprising depositing at least 1.5 mass % of the nano-particles entrained in the helium-air mixture in the animal's lungs.

14. The method of claim 1 wherein the nano-particles are provided as SiO 2 , Fe 3 O 4 , Fe 3 O 4 with carboxylated surface modification, Fe 3 O 4 with amine surface modification, and combinations thereof.

15. The method of claim 1 wherein the dry air comprises at least 30 mol % oxygen.

16. A system for producing a flow of highly concentrated nano-particles comprising:
a Collison nebulizer in communication with a plenum, the plenum provided as having a reduction in the circumference of the plenum,
a port for introducing a helium gas flow into the Collison nebulizer,
a flow of solid nano-particles entrained in the helium gas flow,
an inlet for providing flow of dry air around and in contact with the nano-particles entrained in the helium gas flow in the plenum; and
wherein the reduction in the circumference of the plenum is downstream of the inlet and in the direction of flow from the inlet through the plenum; and wherein, during operation, the reduction in the circumference of the plenum occurs after contact of the dry air with the nanoparticles.

17. The apparatus of claim 16 further comprising a uniformity screen within the plenum and disposed between the inlet and the reduction in the circumference of the plenum.

Assignees

• Mikheev Vladimir B
• Forsythe William C
• Swita Benjamin N
• Battelle Memorial Institute

Inventors

• Mikheev Vladimir B
• Forsythe William C
• Swita Benjamin N

Classifications

• A61M2202/025

  Helium · CPC title

• A61M16/14 Primary

  by mixing different fluids, one of them being in a liquid phase · CPC title

• A61M11/003

  by passing the aerosol trough sieves or filters · CPC title

• A61M15/00

  Inhalators {(drug delivery in endotracheal tubes A61M16/04)} · CPC title

• A61K9/0078 Primary

  for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions · CPC title