Cyclic olefin polymer vessels and vessel coating methods

Patent metadata

Field	Value
Publication number	US-9878101-B2
Application number	US-201113240797-A
Country	US
Kind code	B2
Filing date	Sep 22, 2011
Priority date	Nov 12, 2010
Publication date	Jan 30, 2018
Grant date	Jan 30, 2018

Abstract

A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.

First claim

The invention claimed is:

1. A package containing a pharmaceutical composition, the package comprising:
a container comprising a syringe barrel having a wall defining a lumen, the wall having a wall interior surface consisting essentially of a cyclic olefin polymer (COP) free of co-monomers,
a barrier coating on at least a portion of the wall interior surface, the coating consisting essentially of a material comprising the atomic ratio SiO x measured by X-ray photoelectron spectroscopy (XPS), in which x is from 1.5 to 2.9, and
a plasma enhanced chemical vapor deposition (PECVD) lubricity coating over the barrier coating, comprising the following atomic ratio, measured by XPS,
Si w O x C y

where w is 1, x in this formula is from about 0.5 to 2.4, and y is from about 0.6 to about 3, the wall interior surface coated with the barrier coating and the lubricity coating having at least 25% lower sliding frictional resistance or at least 25% lower breakout frictional resistance than the wall interior surface lacking the barrier coating and the lubricity coating, as measured in accordance with ISO 7886-1:1993; and

a composition contained in the lumen comprising:
one or more active medicaments which are at least one of a protein, a peptide, or a DNA sequence;
a water; and
at least one organic preservative.

2. The package of claim 1 , in which the package further comprises a stopper, plunger or piston located at least partially within the lumen and slidable along the wall interior surface.

3. The package of claim 1 , in which the organic preservative comprises at least one of m-cresol, benzyl alcohol, and phenol.

4. The package of claim 1 , in which the one or more active medicaments comprises pharmaceutical insulin.

5. The package of claim 1 , further comprising a plunger or piston having a front face, a side portion, and a back portion, the side portion being configured to movably seat within the syringe barrel, at least a portion of the front face made of cyclic olefin polymer resin.

6. A medical or diagnostic kit comprising
the package of claim 1 ;
a hypodermic needle, double-ended needle, or other delivery conduit; and
optionally, an instruction sheet.

7. The package of claim 1 , in which the wall is made from a single COP composition.

8. The package of claim 1 , in which the plasma enhanced chemical vapor deposition (PECVD) lubricity coating is a PECVD reaction product employing a gaseous precursor comprising octamethylcyclotetrasiloxane (OMCTS).

Assignees

• Felts John T
• Fisk Thomas E
• Abrams Robert S
• Ferguson John
• Freedman Jonathan R
• Pangborn Robert J
• Sagona Peter J
• Sio2 Medical Products Inc

Inventors

• Felts John T
• Fisk Thomas E
• Abrams Robert S
• Ferguson John
• Freedman Jonathan R
• Pangborn Robert J
• Sagona Peter J

Classifications

• A61M5/3129 Primary

  Syringe barrels (A61M5/3205 and A61M5/50 take precedence) · CPC title

• A61M5/31513

  Piston constructions to improve sealing or sliding · CPC title

• A61M2005/3131

  specially adapted for improving sealing or sliding · CPC title