Detection of targets using magnetic resonance

Patent metadata

Field	Value
Publication number	US-9874564-B2
Application number	US-201214006389-A
Country	US
Kind code	B2
Filing date	Mar 21, 2012
Priority date	Mar 22, 2011
Publication date	Jan 23, 2018
Grant date	Jan 23, 2018

Abstract

A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.

First claim

What is claimed is:

1. A portable magnetic resonance system comprising:
a permanent magnet;
a nuclear magnetic resonance probe; and
control electronics configured to:
transmit to the probe a magnetic resonance excitation signal having an excitation frequency f,
receive from the probe a magnetic resonance measurement signal;
detect in the magnetic resonance measurement signal a magnetic resonance frequency f 0 ; and
automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a predetermined offset,

wherein the control electronics are further configured to measure at least one of a sample longitudinal relaxation time T 1 and a sample transverse relaxation time T 2 from the magnetic resonance measurement signal when the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to the predetermined offset.

2. The magnetic resonance diagnostic system of claim 1 , wherein the control electronics are configured to detect the magnetic resonance frequency f 0 based on a spectral power of the magnetic resonance measurement signal.

3. The magnetic resonance diagnostic system of claim 1 , wherein the nuclear magnetic resonance probe comprises an encapsulating block and a microcoil embedded within the encapsulating block.

4. The magnetic resonance diagnostic system of claim 3 , wherein the encapsulating block comprises polydimethylsiloxane (PDMS).

5. The magnetic resonance diagnostic system of claim 3 , wherein the encapsulating block comprises a bore for receiving a sample container.

6. The magnetic resonance diagnostic system of claim 5 , wherein the microcoil surrounds the bore.

7. The magnetic resonance diagnostic system of claim 1 , wherein the permanent magnet comprises an opening configured to receive the nuclear magnetic resonance probe.

8. The magnetic resonance diagnostic system of claim 1 , wherein the opening extends from a first side of the magnet through the magnet center to a second opposite side of the magnet.

9. The magnetic resonance diagnostic system of claim 1 , further comprising a microfluidic network configured to contain a sample fluid.

10. The magnetic resonance diagnostic system of claim 1 , further comprising a portable data processing device to communicate with the control electronics, wherein the portable data processing device is operable to:
transmit one or more commands to the control electronics to initiate measurement of at least one of a sample longitudinal relaxation time T 1 or a sample transverse relaxation time T 2 ;
receive from the control electronics data corresponding to the sample longitudinal relaxation time T 1 or the sample transverse relaxation time T 2 , or both; and
output the data to a display.

11. A portable magnetic resonance system comprising:
a nuclear magnetic resonance probe comprising a microcoil assembly and a sample receiving area, wherein the microcoil assembly surrounds the sample receiving area; and
control electronics configured to:
transmit to the probe a magnetic resonance excitation signal having an excitation frequency f,
receive from the probe a magnetic resonance measurement signal;
detect in the magnetic resonance measurement signal a magnetic resonance frequency f 0 ; and
automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a predetermined offset.

12. The portable magnetic resonance system of claim 11 , further comprising a magnet having an opening, wherein the nuclear magnetic resonance probe is positioned within the opening in the magnet.

Assignees

• Weissleder Ralph
• Lee Hakho
• Issadore David
• Massachusetts Gen Hospital

Inventors

• Weissleder Ralph
• Lee Hakho
• Issadore David

Classifications

• G01N2800/00

  Detection or diagnosis of diseases · CPC title

• G01N2800/52

  Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title

• G01N33/5759

  involving compounds localised on the membrane of tumour or cancer cells · CPC title

• G01N33/5758 Primary

  involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites · CPC title

• G01N33/575 Primary

  for cancer · CPC title