1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3- Dioxygenase
US-2016220543-A1 · Aug 4, 2016 · US
Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US9873688B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9873688-B2 |
| Application number | US-201615093486-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 7, 2016 |
| Priority date | Nov 8, 2013 |
| Publication date | Jan 23, 2018 |
| Grant date | Jan 23, 2018 |
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- Title
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Abstract
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The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
First claim
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What is claimed is: 1. A compound of Formula F18: wherein R 4 is benzyl, ethyl, C 1-3 haloalkyl, 2,2,2-trichloroethyl or 9H-fluoren-9-ylmethyl. 2. The compound of claim 1 , wherein R 4 is benzyl. 3. The compound of claim 1 , wherein R 4 is ethyl. 4. The compound of claim 1 , wherein R 4 is C 1-3 haloalkyl. 5. The compound of claim 1 , wherein R 4 is 2,2,2-trichloro ethyl. 6. The compound of claim 1 , wherein R 4 is 9H-fluoren-9-ylmethyl.
Assignees
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Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Antineoplastic agents · CPC title
- C07D271/06Primary
1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles · CPC title
having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms · CPC title
- A61K31/4245Primary
Oxadiazoles · CPC title
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- What does patent US9873688B2 cover?
- The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
- Who is the assignee on this patent?
- Incyte Corp, Incyte Holdings Corp
- What technology area does this patent fall under?
- Primary CPC classification C07D271/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 23 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).