Electroosmotic convection-enhanced delivery system

Patent metadata

Field	Value
Publication number	US-9872982-B2
Application number	US-201313738720-A
Country	US
Kind code	B2
Filing date	Jan 10, 2013
Priority date	Jan 10, 2012
Publication date	Jan 23, 2018
Grant date	Jan 23, 2018

Abstract

Apparatuses and methods for electrokinetic transport of fluids to patients. Drug-containing solutions may be placed in vial-like reservoir, which is connected to an apparatus such as a traditional catheter or other device capable of holding a drug-containing solution. Instead of a vial-like reservoir, a doped infusion pad or a gel may be used as a source of the drug-containing solution. The reservoir and apparatus may thus be the same component. The methods and apparatuses disclosed herein may also be used to transport fluid alone to achieve a clinical effect. The apparatus is placed at the point of drug delivery. The counter-electrode may be placed in or on a patient. Current is passed from the reservoir to the counter-electrode. Through electrokinetic transport, drug-containing solution is delivered along a current path from the drug source to the counter-electrode. A hollow fiber catheter for use in electrokinetic transport is also disclosed.

First claim

The invention claimed is:

1. A method of administering a fluid to a tissue, comprising:
inserting a blunt end of a distal portion of at least one fluid passage defined by a hollow fiber into a target tissue at a first position in a subject;
fluidically coupling a proximal portion of the at least one fluid passage defined by the hollow fiber to a fluid reservoir with a catheter, wherein a support rod is situated in lumens of the hollow fiber and the catheter;
placing a counter-electrode at a second subject position, wherein the fluid reservoir and the counter-electrode are operably connected to a current source;
applying a current to the fluid reservoir; and
allowing the fluid to be transported into the tissue in response to the applied current.

2. The method of claim 1 , wherein said tissue is a neural tissue.

3. The method of claim 1 , further comprising implanting the catheter in said target tissue.

4. The method of claim 1 , wherein a path between said first position and said second position defines a trajectory along with an electrokinetic transport occurs.

5. The method of claim 1 , wherein said fluid is a drug-containing fluid.

6. The method of claim 5 , wherein said drug is a small molecule or a peptide.

7. The method of claim 6 , wherein said small molecule is a chemotherapeutic compound, a local anesthetic, a neurotransmitter, or a steroid.

8. The method of claim 6 , wherein said peptide is a neurotransmitter, an antibody, or a signaling peptide.

9. The method of claim 5 , wherein said drug is a positively charged molecule.

10. The method of claim 5 , wherein said drug is a neutral molecule.

11. The method of claim 5 , wherein said drug is a negatively charged molecule.

12. The method of claim 5 , wherein said drug-containing fluid includes a drug in a formulation of nanoparticles or liposomes.

13. The method of claim 1 , wherein the fluid reservoir situated remote from said subject and the current is directed to the fluid in the fluid reservoir with an electrode situated at the fluid reservoir.

14. The method of claim 1 , wherein the current is directed toward the subject from said fluid reservoir situated external to said subject through the at least one fluid passage.

15. The method of claim 1 , wherein the current is directed between the fluid reservoir and the tissue through the fluid passage defined in the hollow fiber.

16. The method of claim 1 , further comprising providing the fluid reservoir in a first compartment of a vial, wherein the vial includes a second compartment and a separator situated between the first compartment and the second compartment, wherein an electrode is situated in the second compartment so that the current is applied to the first compartment of the fluid reservoir from the second compartment of the fluid reservoir through the separator with the electrode in the second compartment.

17. The method of claim 1 , wherein the fluid passage is defined by a methacrylate-, acrylate-, or sulfonate-containing polymer.

18. The method of claim 1 , wherein the fluid passage is defined by an anionic surface.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Weber Stephen
• Faraji Amir H
• Guy Yifat
• Jaquins-Gerstl Andrea
• Valenta Alec C

Classifications

• A61N1/325 Primary

  for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body (electrodes for external use A61N1/0428) · CPC title

• A61N1/306

  Arrangements where at least part of the apparatus is introduced into the body · CPC title

• A61M2037/0007

  having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents · CPC title

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title