Hydrogel-forming material, premix, and hydrogel formation method

Patent metadata

Field	Value
Publication number	US-9872907-B2
Application number	US-201314433529-A
Country	US
Kind code	B2
Filing date	Oct 2, 2013
Priority date	Oct 3, 2012
Publication date	Jan 23, 2018
Grant date	Jan 23, 2018

Abstract

A hydrogel-forming material, a premix, and a method for forming a hydrogel through a simple process at room temperature. The material including: a disperse phase (A) including a lipid peptide-based gelator including at least one of a compound of Formula (1) or pharmaceutically usable salt thereof, water, and a fatty acid salt; and a phase (B) that includes a water-soluble acidic polymer:

(where R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group that optionally has a C 1-2 branched chain, R 3 is a —(CH 2 ) n —X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a —CONH 2 group, a 5-membered ring optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s)).

First claim

The invention claimed is:

1. A hydrogel-forming material comprising:
(i) a disperse phase (A) including 0.2 to 0.5% by mass, relative to a total mass of a formed hydrogel, of a lipid peptide-based gelator consisting of a compound of Formula (1) or a pharmaceutically usable salt thereof, water, and 0.1 to 0.25% by mass, relative to the total mass of the formed hydrogel, of a fatty acid salt, and
a disperse phase (B) that includes 0.1 to 0.2% by mass, relative to the total mass of the formed hydrogel, of a carboxyvinyl polymer increasing viscosity by neutralization; or
(ii) a disperse phase (A) including 0.3 to 0.5% by mass, relative to a total mass of a formed hydrogel, of a lipid peptide-based gelator consisting of a compound of Formula (1) or a pharmaceutically usable salt thereof, water, and 0.1 to 0.305% by mass, relative to the total mass of the formed hydrogel, of a fatty acid salt, and
a disperse phase (B) that includes 0.2% by mass, relative to the total mass of the formed hydrogel, of an acrylic acid-alkyl methacrylate copolymer increasing viscosity by neutralization, or 0.1 to 0.5% by mass, relative to the total mass of the formed hydrogel, of a polyacrylic acid increasing viscosity by neutralization:

where R 1 is a C 9-23 aliphatic group, R 2 is a hydrogen atom or a C 1-4 alkyl group that optionally has a C 1-2 branched chain, R 3 is a —(CH 2 ) n —X group, n is a number of 1 to 4, X is an amino group, a guanidino group, a —CONH 2 group, a 5-membered ring optionally containing 1 to 3 nitrogen atom(s), a 6-membered ring optionally containing 1 to 3 nitrogen atom(s), or a condensed heterocycle that contains a 5-membered ring and a 6-membered ring optionally containing 1 to 3 nitrogen atom(s).

2. The hydrogel-forming material according to claim 1 , wherein the fatty acid salt is selected from the group consisting of butyrates, valerates, caproates, enanthates, caprylates, pelargonates, caprates, laurates, myristates, pentadecylates, palmitates, palmitoleates, margarates, stearates, oleates, vaccenates, linoleates, (9,12,15)-linolenates, (6,9,12)-linolenates, eleostearates, tuberculostearates, arachidates, arachidonates, behenates, lignocerates, nervonates, cerotates, montanates, and melissates.

3. The hydrogel-forming material according to claim 1 , wherein the disperse phase (A) further includes a polyhydric alcohol.

4. The hydrogel-forming material according to claim 1 , wherein the disperse phase (B) further includes a polyhydric alcohol.

5. A method for producing a hydrogel comprising:
preparing the disperse phase (A) including a lipid peptide-based gelator, water, and a fatty acid salt as claimed in claim 1 ;
adding the disperse phase (B) including a water-soluble acidic polymer as claimed in claim 1 to the disperse phase (A); and
stirring the resulting mixture at room temperature and then leaving the resulting mixture still standing to form a hydrogel.

6. The method for producing a hydrogel according to claim 5 , wherein preparation of the disperse phase (A) is performed by mixing the lipid peptide-based gelator, water, and the fatty acid salt at a high temperature with stirring and then leaving the resulting mixture to cool to reach room temperature.

7. A hydrogel formed from the hydrogel-forming material as claimed in claim 1 .

8. A hydrogel formed from the hydrogel-forming material as claimed in claim 2 .

9. A hydrogel formed from the hydrogel-forming material as claimed in claim 3 .

10. A hydrogel formed from the hydrogel-forming material as claimed in claim 4 .

Assignees

• Nissan Chemical Ind Ltd

Inventors

• Matsumoto Keigo
• Kashino Tsubasa

Classifications

• A61L15/34

  Oils, fats, waxes or natural resins {(A61L15/225 takes precedence)} · CPC title

• A61K8/37

  Esters of carboxylic acids · CPC title

• A61K2800/10

  General cosmetic use · CPC title

• C08K5/098

  Metal salts of carboxylic acids · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title