Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid

Patent metadata

Field	Value
Publication number	US-9872872-B2
Application number	US-201514879280-A
Country	US
Kind code	B2
Filing date	Oct 9, 2015
Priority date	Sep 3, 2009
Publication date	Jan 23, 2018
Grant date	Jan 23, 2018

Abstract

The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

First claim

What is claimed is:

1. A particulate composition comprising anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid,
which comprises 2-O-α-D-glucosyl-L-ascorbic acid in an amount of over 98.0% by weight but 99.8% by weight or lower, on a dry solid basis;
which has a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of said composition;
which contains particles with a particle size of less than 150 μm in an amount of 70% by weight or higher to the whole particulate composition, and those with a particle size of at least 53 μm but less than 150 μm in an amount of 40 to 60% by weight to the whole composition; and
which has a reducing power of the whole composition being less than one percent by weight.

Assignees

• Hayashibara Co

Inventors

• Shibuya Takashi
• Izawa Seisuke
• Nishimoto Tomoyuki
• Fukuda Shigeharu
• Miyake Toshio

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• C12P19/18

  produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins · CPC title

• C07H17/04 Primary

  Heterocyclic radicals containing only oxygen as ring hetero atoms · CPC title

• C12Y204/01019

  Cyclomaltodextrin glucanotransferase (2.4.1.19) · CPC title